摘要
以2-乙基苯胺为原料,经硝化、环合和甲基化反应制得2,3-二甲基-N-(2-氯嘧啶-4-基)-N-甲基-2H-吲唑-6-胺(8);8与2-甲基-5-氨基苯磺酰胺经缩合和成盐反应合成了盐酸帕唑帕尼,总收率39.6%,其结构经1H NMR和MS确证。
Pazopanib hydrochloride in total yield of 39. 6% was synthesized by condensation and salification of 2-methyl-5-aminobenzene sulfonamide with 2,3-dimethyl-N-( 2-chloropyrimidin-4-yl-Nmethyl-2H-indazol-6-amine),which was obtained from 2-ethylaniline by nitration,cyclization and methylation. The structure was confirmed by1H NMR and MS.
出处
《合成化学》
CAS
CSCD
北大核心
2014年第1期121-123,共3页
Chinese Journal of Synthetic Chemistry
基金
浙江自然科学基金资助项目(LY12B02020)
浙江绿色制药工艺科技创新团队项目(2012R10043-10)