血管紧张素原基因M235T多态性与肥厚型心肌病关系的Meta分析

Meta-analysis on association between angiotensinogen gene M235T polymorphism and hypertrophic cardiomyopathy

目的：系统评价血管紧张素原（AGT）基因M235T多态性与肥厚型心肌病（HCM）的相关性，为HCM的防治提供依据。方法：检索PubMed、Embase、OVID、Web of Science、Cochranelibrary、CNKI、万方及VIP数据库，搜集有关AGTM235T多态性与HCM关系研究的文献，对符合纳入标准的文献采用Stata11.0软件进行Meta分析。结果：共纳入8篇文献，累计病例887例，对照组1407例。Meta分析，M235T基因多态性与HCM的相关性差异无统计学意义[T vs M：OR=1．17，95％CI=0．95～1．45；（TT／MT） vs MM：OR=1．12，95％CI=0．87～1．45；TT vs（MM／MT）：OR=1.21，95％CI—1．00～1．45；MT vs MM：OR=1．07，95％CI=0．82～1．41；TT vs MM：OR=1．25，95％CI=0．79～1．99]。亚组分析，M235T基因多态性与亚洲人群和散发性肥厚型心肌病（SHCM）有关，差异均有统计学意义（P〈0．05），在欧洲和家族性肥厚型心肌病（FHCM）人群中差异无统计学意义（P〉0．05）。结论：在全人群中AGTM235T多态性与HCM的发病无关联，但是在亚洲和SHCM的人群中M235T多态性与HCM的发病有关。

Objective To investigate the relationship between angiotensinogen （AGT） gene M235T polymorphism and hypertrophic cardiomyopathy （HCM） and to provide evidence for prevention and treatment of HCM. Methods PubMed, Embase, OVID, Web of Science, Cochranelibrary, CNKI, WangFang Data and VIP were searched to identify the studies about the relationship between AGT M235T polymorphism and HCM. The studies that met the inclusion criteria were used for Meta-analysis with Stata 11.0 software. Results Eight studies were included, which involved 887 cases and 1 407 controls. The Meta-analysis results indicated that there was no significant association between AGT M235T polymorphism and HCM （T vs M.. OR= 1.17, 95%CI= 0.95- 1.45; （TT/MT） vs MM： OR=1.12, 95%CI=0.87--1.45; TTvs （MM/MT）： OR=l. 21, 95%CI=1.00-- 1.45; MTvs MM： OR=1.07, 95%CI=0.82--1.41; TT vs MM ： OR=1.25, 95%CI=0.79--1.99. In subgroup analysis, the significant difference of association between AGT M235T polymorphism and HCM existed in Asian and sporadic hypertrophic cardiomyopathy （SHCM）, but no significant difference was found in European and familial hypertrophic cardiomyopathy （FHCM）. Conclusion There is no association between HCM and AGT M235T polymorphism in populations, but such a relationship exists in Asians and SHCM.