期刊文献+

Ghrelin在糖尿病肾病中的研究进展

原文传递
导出
摘要 随着人们生活水平的提高、生活方式的改变和寿命的延长,肥胖症、糖尿病等代谢性疾病的患病率逐年上升.糖尿病现已成为位于心脑血管疾病、肿瘤后第三位高病死率的疾病,而糖尿病肾病(DN)及其导致的肾功能不全更是严重影响糖尿病患者的生存质量及导致死亡的重要原因.目前,有关胃肠道激素与糖尿病及DN的研究多有报道,其中Ghrelin在糖尿病及其并发症方面的研究深受内分泌界的关注,现已经成为了一个热点问题.现就DN患者血Ghrelin水平的研究进展进行综述.
出处 《中国医师进修杂志》 2014年第4期76-77,共2页 Chinese Journal of Postgraduates of Medicine
  • 相关文献

参考文献21

  • 1Yang W,Lu J,Weng J. Prevalence of diabetes among men and women in China[J].{H}New England Journal of Medicine,2010,(12):1090-1101.
  • 2Shaw JE,Sicree RA,Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030[J].{H}Diabetes Research and Clinical Practice,2010,(1):4-14.
  • 3Collins AJ,Kasiske B,Herzog C. Excerpts from the United States Renal Data System 2006 Annual Data Report[J].{H}American Journal of Kidney Disease,2007,(1 Suppl 1):S1-296.
  • 4Mogensen CE. How to protect the kidney in diabetic patients:with special reference to IDDM[J].{H}DIABETES,1997,(Suppl 2):S104-S111.
  • 5Kojima M,Kangawa K. Structure and function of ghrelin[J].{H}Results and Problems in Cell Differentiation,2008.89-115.
  • 6Asakawa A,Inui A,Fujimiya M. Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin[J].{H}GUT,2005,(1):18-24.
  • 7Kojima M,Kangawa K. Ghrelin:structure and function[J].{H}Physiological Reviews,2005,(2):495-522.
  • 8Nakazato M,Murakami N,Date Y. A role for ghrelin in the central regulation of feeding[J].{H}NATURE,2001,(6817):194-198.
  • 9Cummings DE,Weigle DS,Frayo RS. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery[J].{H}New England Journal of Medicine,2002,(21):1623-1630.
  • 10Wren AM,Seal LJ,Cohen MA. Ghrelin enhances appetite and increases food intake in humans[J].{H}Journal of Clinical Endocrinology and Metabolism,2001,(12):5992.

二级参考文献36

  • 1Dezaki K, Kakei M, Yada T. Ghrelin uses Ga i2 and activates voltage - dependent K + channels to attenuate glucose - induced Ca2 + signaling and insulin release in islet beta - ceils : novel signal transduction of gh- relin [J]. Diabetes, 2007, 56 (9): 2319-2327.
  • 2Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth - hormone - releasing acylated peptide from stomach [ J 1. Nature, 1999, 402 (6762) : 656 -660.
  • 3Poykko SM, Kellokoski E, Horkko S, et al. Low plasma ghrelin is as- sociated with insulin resistance, hypertension, and the prevalence of type2 diabetes [J]. Diabetes, 2003, 52 (10): 2546-2553.
  • 4Firczyk P, Lgnacy W, Adamczak M, et al. Postprandial secretion of ghrelin in hemodialysis patients with and without diabetic nephropathy [J]. Pol Arch Med Wewn, 2009, 119 (7/8) : 447 -452.
  • 5Kuloglu T, Dabak DO. Determination of ghrelin immunoreactivity in kid- ney tissues of diabetic rats [ J ]. Renal Failure, 2009, 31 ( 7 ) : 562 - 566.
  • 6Sarabeimo M, Forsblom C, Thorn L, et al. Serum adiponectin and / progression of diabetic nephropathy in patients with type 1 diabetes [ J ] . Diabetes Care, 2008, 31 (6) : 1165 -1169.
  • 7Risch L, Saely C, Hoefie G, et al. Relationship between glomerular filtration rate and the adipokines adiponectin, adiponectin and leptin in coronary patients with predominantly normal or mildly impaired renalfunction [J]. Clinica Chimica Acta, 2007, 376:108-113.
  • 8Kojima M,Hosoda H,Date Yukari,et al.Ghrelin is a growth hormone-releasing acylated peptide from stomach[J].Nature,1999,402(6762):656-660.
  • 9Gando RG,Aguiar 0liverira MH,Hayashida CY,et al.Growth hormone-releasing peptide-2 stimulates GH secretion in GHreleasing hormone receptor[J].J Clin Endocrinol Metab,2001,86(3):3279-3283.
  • 10Cummings DE,Weigle DS,Frayo RS,et al.Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery[J].New Engl J Med,2002,346(21):1623-1630.

共引文献26

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部