槐耳颗粒联合化疗栓塞术治疗原发性肝癌96例

Huaier Granules Combined with Chemoembolization in Treating Primary Liver Cancer in 96 Cases

目的研究槐耳颗粒联合化疗栓塞术治疗原发性肝癌的临床疗效和安全性,并探讨其作用机制。方法将96例肝癌患者随机分成试验组与对照组,各48例。对照组采用化疗栓塞术治疗,试验组加服槐耳颗粒。比较两组患者的总有效率、生存质量、免疫水平、复发率、生存率和不良反应发生情况。结果试验组的总有效率为66.67%,明显高于对照组的45.83%(P<0.05);试验组患者生存质量、免疫水平和生存率均明显高于对照组(P<0.05);试验组发生消化道不良反应、骨髓抑制和肝功能损害的病例数均明显少于对照组(P<0.05)。结论槐耳颗粒联合化疗栓塞术治疗原发性肝癌,能促进瘤体坏死、提高患者自身免疫力、改善生存质量,且不良反应较小,值得临床推广。

Objective To study the clinical efficacy and safety of Huaier Granules combined with chemoembolization in treating primary hver cancer and to explore the involved mechanism. Methods Ninety- six patients with liver cancer were randomly divided into the treatment group and the control group,48 cases in each group. The control group used the chemoembolization therapy and the treatment group received additional Huaier Granules treatment. The total effective rate, quality of life, immunity level, recurrence rates, survival rates and occurrence of adverse reactions were compared between the two groups. Results The total effective rate was 66.67% in the treat- ment group and 45.83% in the control group, the difference between them had statistically significant（P〈 0. 05）; the quality of life, immunity level and survival rate in the treatment group were higher than those in the control group（ P 〈 0. 05）; the cases of digestive tract adverse reactions, bone marrow suppression and liver function damage in the treatment group were less than those in the control group（ P 〈 0. 05）. Conclusion Huaier Granules combined with chemoembolization in treating primary liver cancer could promote tumor necrosis, increase the patient＇s own immunity and improve the living quality with little adverse reactions, which is worth for promoting in clinical practice.