生物蛋白胶联合明胶海绵治疗食管癌术后消化道瘘27例

Comparison of Curative Effects of Fibrin Glue Combined with Gelfoam and Traditional Method in Treating Postoperative Digestive Tract Fistulas of Esophageal Carcinoma

目的探讨生物蛋白胶联合明胶海绵与传统常规方法治疗食管癌术后消化道瘘的疗效。方法选取近10年来食管癌术后消化道瘘患者50例(胸内吻合口瘘28例、胸内胃瘘8例、颈部吻合口瘘14例),23例给予传统常规治疗,27例应用生物蛋白胶加明胶海绵粘堵法治疗。结果应用生物蛋白胶加明胶海绵治疗消化道瘘的均得到治愈,且愈合时间明显短于传统治疗方法(P<0.05),随访3个月消化道瘘无复发。结论采用医用生物蛋白胶联合明胶海绵对消化道瘘进行粘堵,相对于传统常规方法,加快了瘘的愈合时间,是一种安全、有效的方法,能有效减轻患者的痛苦和经济负担。

Objective To study and compare the effects of fibrin glue combined with gelfoam and the traditional method for treating postoperative digestive tract fistulas of esophageal carcinoma. Methods Fifty patients with digestive tract fistulas（28 cases of intratho- racic anastomotic fistula, 8 cases of intrathoracic gastric fistula and 14 cases of neck anastomotic fistula） after esophageal carcinoma op- eration in the recent ten years were selected and divided into the traditional therapy group（23 cases） and the fibrin glue combined with gelfoam group（27 cases）. Results Digestive tract fistulas in the fibrin glue combined with gelfoam group were cured, and their heal- ing time was significantly short than that in the traditional therapy group, the difference between groups had statistical significance（ P 〈 0.05）. Digestive fistulas had no relapse during 3- months follow up. Conclusion Compared with the traditional method, adopting the medical fibrin glue combined with gelfoam for conducting adhesion and plugging on digestive tract fistula accelerates the fistula healing time, which is a safe and effective method and can effectively alleviate the patient＇s pain and economical burden.