透明质酸钠结合功能训练治疗膝骨关节炎50例

Clinical Efficacy of Sodium Hyaluronate Combined with Functional Training in Treating Knee Osteoarthritis in 50 Cases

目的观察透明质酸钠关节腔内注射结合功能训练治疗膝骨关节炎的临床疗效。方法将50例膝骨关节炎(77膝)患者随机分为两组,对照组25例(38膝)给予透明质酸钠膝关节腔内注射,每次2 mL,每周1次;治疗组25例(39膝)给予透明质酸钠关节腔内注射与功能训练,两组疗程均为5周。采用加拿大骨关节炎指数评分法(WOMAC)进行评分,以治疗前后评分差值为临床疗效判定依据,并比较两组改善疼痛、关节僵硬、生理功能的情况。结果治疗后对照组和治疗组的改善率分别为76.00%和92.00%(P<0.05);术后3个月对照组、治疗组改善率为68.00%和88.00%(P<0.05)。治疗后及术后3个月治疗组在改善疼痛、关节僵硬、生理功能方面均优于对照组(P<0.01)。结论透明质酸钠关节腔内注射与功能训练治疗膝骨关节炎取得了较好的近期疗效,可提高患者生活质量。

Objective To observe the clinical efficacy of sodium hyaluronate intra- articular injection combined with functional training in treating knee osteoarthritis. Methods Fifty patients with knee osteoarthritis （77 knees） were randomly divided into two groups. 25 cases（38 knees） in the control group were given sodium hyaluronate by knee intra-articular injection, 2 mL per time, once a week; 25 cases （39 knees） in the treatment group were given sodinm hyaluronate by knee intra-articular injection and the functional train- ing. The two groups were treated for 5 weeks. The WOMAC score was adopted to conduct the evaluation and the difference between be- fore and after treatment was used as the basis for evaluating the clinical curative efficacy. Furthermore the improvement of pain, joint stiffness and physiological function was compared between the two groups. Results The improvement rate after treatment in the control group and the treatment group were 76. 0% and 92% respectively（P 〈 0. 05）;which in postoperative 3 months were 68% and 88. 0% （P 〈 0. 05）. The treatment group was better than the control group in the aspects of improving pain, joint stiffness and physical function after treatment and in 3 months after treatment（ P 〈 0. 01 ）. Conclusion Sodium hyalnronate by intra- articular injection combined with the functional training has a better short- term effect for treating knee osteoarthritis and can improve patients＇ life quality.