天麻素注射液联合前列地尔注射液治疗短暂性脑缺血发作疗效观察被引量：5

Effect of Gastrodin Injection Combined with Alprostadil Injection on Transient Ischemic Attack

下载PDF

导出

摘要目的观察天麻素注射液联合前列地尔注射液治疗短暂性脑缺血发作(TIA)的临床疗效。方法选取2010年5月—2013年4月我院神经内科收治的TIA患者96例,将其按照就诊顺序分为治疗组和对照组,各48例。对照组采用胞磷胆碱联合复方丹参注射液治疗,治疗组采用天麻素注射液联合前列地尔注射液治疗。两组疗程均为14d,并比较两组疗效。结果治疗组总有效率为91.7%(44/48),高于对照组的77.1%(37/48)(χ2=6.173,P=0.046)。两组患者均未发现不良反应。结论天麻素注射液联合前列地尔注射液治疗TIA效果好,不良反应少,值得临床推广应用。 Objective To observe the effect of gastrodin injection combined with alprostadil injection on transient is- chemic attack （TIA）. Methods 96 patients with TIA in our hospital of nerve internal medicine from May 2010 to April 2013 were divided into groups treatment and control according to the treatment order, each of 48 cases. Control group was given eitico- line and compound danshen injection, treatment group was given gastrodin injection and alprostadil injection. Both treated for 14 days, and the effect between two groups was compared. Results The total efficacy of treatment group was 91.7% （44/48） , was higher than that of control group of 77. 1% （37/48）（χ2 = 6. 173, P = 0. 046）. Adverse reactions were not noted in two groups. Conclusion Gastrodin injection combined with alprostadil injection has satisfactory effect, and less side effects on tran- sient ischemic attack, being worthy of promotion.

作者杨树萍侯志东王永

机构地区江苏省新沂市人民医院新沂市铁路医院

出处《实用心脑肺血管病杂志》 2014年第2期42-43,共2页 Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

关键词脑缺血发作短暂性天麻素注射液前列地尔注射液治疗结果 Ischemic attack, transient Gastrodin injection Alprostadil injection Treatment outcome

分类号 R743.31 [医药卫生—神经病学与精神病学]

引文网络
相关文献

参考文献9

1Johnston DC, Hill MD. The patient with transient cerebral ischemia: a golden opportunity for stroke prevention [ J ]. CMAJ, 2004, 170 (7): 1134 - 1137.
2各类脑血管疾病诊断要点[J].中华神经科杂志,1996,29(6):379-380. 被引量：33024
3Liang J, Yao J, Wang G, et al. Ischemic postconditioning protects neuronal death caused by cerebral ischemia and reperfusion via attenua- ting protein aggregation [J]. Int J Med Sci, 2012, 9 (10): 923- 932.
4Suzuki Y, Hattori K, Hamanaka J, et al. Pharmacological inhibition of TLR4 - NOX4 signal protects against neuronal death in transient focal ischemia [J]. Sci Rep, 2012 (2): 896.
5Zeng X, Zhang S, Zhang L, et al. A study of the neuroprotective effect of the phenolic glucoside gastrodin during cerebral isehemia in vivo and in vitro [J]. Planta Med, 2006, 72 (15) : 1359 -1365.
6Zeng X, Zhang Y, Zhang S, et al. A microdialysis study of effects of gastrodin on neurochemical changes in the ischemic/reperfused rat cere- bral hilaoocampus [J]. Biol Pharm Bull. 2007. 30 (4): 801-804.
7李惠允,周华东.前列地尔脂微球注射液对急性脑梗死患者肿瘤坏死因子-α水平的影响及临床意义[J].中国全科医学,2011,14(27):3151-3153. 被引量：14
8邱彩玲.前列地尔治疗急性脑梗死的临床疗效研究[J].实用心脑肺血管病杂志,2012,20(2):237-238. 被引量：15
9Hamamoto Y, Ogata T, Morino T, et al. Prostaglandin E1 analog in- creases spinal cord blood flow at the point of compression during and after experimental spinal cord injury [J]. Spinal Cord, 2010, 48 (2) : 149 - 153.