摘要
目的观察度洛西汀联合认知疗法治疗持续性躯体形式疼痛障碍(PSPD)的效果。方法选择2012年8月—2013年3月在我院门诊就诊的PSPD患者70例,将其随机分为研究组和对照组。两组均应用度洛西汀治疗,起始剂量为30 mg/d;在此基础上研究组联合认知疗法。以治疗6周末疼痛量表(MOSPE)减分率评定疼痛疗效,两组患者均在治疗前、治疗2周、4周、6周末采用汉密尔顿抑郁量表(HAMD)评分。结果治疗6周末研究组有效率为82.9%(29/35),对照组有效率为77.1%(27/35),两组有效率比较,差异无统计学意义(χ2=0.36,P>0.05)。治疗4周、6周时,研究组HAMD评分低于对照组(P<0.05)。结论度洛西汀适用于PSPD的治疗,且疗效较好,耐受性较好,联合认知疗法有助于尽快改善患者的抑郁症状。
Objective To observe the effect of duloxetine combined with cognitive therapy on persistent somatoform pain disorder （PSPD）. Methods 70 patients with PSPD admitted to our hospital from August 2012 to March 2013 were ran- domly divided into groups study and control. Both groups were given duloxetine, starting dose was 30 mg/d ; study group was given cognitive therapy on the basis of control group. The pain effect was evaluated by pain scale （MOSPE） after 6 weeks treat- ment. Both were applied Hamihon depression scale （HAMD） before and 2, 4, 6 weeks after treatment. Results The efficacy of groups study and control was 82.9% （29/35） and 77. 1% （27/35）. There was no satistically significant difference in effi- cacy between two groups （χ2 =0. 36, P 〉 0.05） . HAMD score of study group was lower than that of control group 4, 6 weeks after treatment （P 〈0. 05）. Conclusion Duloxetine has better effect and tolerance on PSPD, and is helpful to improve the de- pressive symptoms when combined with cognitive therapy.
出处
《实用心脑肺血管病杂志》
2014年第2期72-73,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
