住院的酒精性肝病患者临床疾病特点分析

Analysis of clinical features of inpatients with alcoholic liver diseases

目的分析住院的酒精性肝病患者临床疾病的特点。方法对近10年收治的4379例各种酒精性肝病患者的疾病构成情况进行分析。结果 2002年住院的酒精性肝病患者占住院的肝病患者的比例为1.74%,2006年为2.89%,2011年为4.18%,10年间上升了2.4倍;在酒精性肝病患者中,男性占97.69%(4278/4379);酒精性肝硬化、酒精性肝病(未分类)、轻症酒精性肝炎为3种最常见的病种,分别占70.66%、10.44%和9.96%,而重症酒精性肝炎、酒精性肝衰竭和酒精性脂肪肝占比为4%左右;酒精性肝硬化患者平均年龄为49.6岁,而酒精性肝病重叠非酒精性脂肪性肝病患者平均年龄为36.9岁,两者差异有统计学意义(P<0.01);轻症酒精性肝炎和酒精性脂肪肝治愈率分别为80.28%和91.58%,而重症酒精性肝炎为47.78%,差异有统计学意义(P<0.01)。结论住院的酒精性肝病患者占住院肝病患者的比例在不断上升,须重视对男性人群和疾病的早期干预。

Objective To analyze the clinical features of inpatients with alcoholic liver diseases（ALD）. Methods Clinical data of inpatients with alcoholic liver diseases in our hospital from 2002 to 2011 were ana-lyzed. Results The ratio of patients with ALD to total inpatients with liver diseases was 1.74% in 2002 and 2.89%in 2006,and it reached to 4.18% in 2011,a 2.4-fold increase in ten years;The percentage of male patients was 97.69%（4278/4379）;Patients diagnosed as alcoholic cirrhosis,ALD （without classification） and mild alcoholic hep-atitis accounted for about 70.66%,10.44% and 9.96% of all ALD patients,and only about 4% of patients were diagnosed as severe alcoholic hepatitis or alcoholic liver failure or alcoholic steatosis （P〈0.01）;The average age of patients with alcoholic cirrhosis was 49.6 year-old,significantly greater than that in patients with ALD complicated by non-alcoholic fatty liver disease（36.9 year-old,P〈0.01）;The recovery rates in patients with mild alcoholic hep-atitis and alcoholic steatosis were 80.28% and 91.58%,respectively,significantly higher than that in patients with severe alcoholic hepatitis（47.78%,P〈0.01）. Conclusions The ratio of ALD inpatients to total inpatients with liver diseases is increasing gradually and more attention should be pay to male patients and patients with mild ALD to prevent disease progress.