肺炎支原体肺炎患儿血清中两种检测指标变化的临床意义

目的：探讨白细胞介素-5（IL-5）和血管内皮生长因子（VEFG）在肺炎支原体肺炎（MPP）发病机制中的作用。方法将120例肺部感染患儿分成3组，每组40例，观察1组为伴喘息的MPP患儿，观察2组为不伴有喘息的MPP患儿，对照组为临床排除MPP的不伴有喘息的支气管肺炎患儿，分别测定三组患儿血清中IL-5和VEFG水平。结果观察1组血清IL-5和VEGF水平高于观察2组（t=35.46、61.97，P〈0.01），差异有统计学意义，观察2组血清IL-5和VEGF水平与对照组比较，差异无统计学意义（t=1.08、0.71，P〈0.05）。结论肺炎支原体肺炎是一种免疫机制参与的全身性疾病，细胞因子IL-5和VEGF在肺炎支原体肺炎患儿喘息的发生和发展中起着重要作用。

Objective To investigate the effect of pathogenesy of interleukin-5（IL-5）and vascular endothelial growth factor （VEFG）in Mycoplasma pneumoniae pneumonia（MPP）. Methods 120 children with pulmonary infection were divided into 3 groups,40 cases were in each group,the children with MPP with wheezing were admitted as the observation group 1,the children with MPP and without wheezing were admitted as the observation group 2,the control group included the children with bronchial pneumonia and no asthmatic that precluded MPP,measured the levels of serum IL-5 and VEFG in three groups respectively. Results serum IL-5 and VEGF levels of the patients in the observation group 1 were higher than that of the observation group 2（t=35.46, 61.97,P〈0.01）,there were significant differences,compared serum IL-5 and VEGF levels of the observation group 2 with the control group,there were no significant differences（t=1.08,0.71,P〈0.05）.Conclusion Mycoplasma pneumonia is a systemic disease with immune mechanism involved,cytokine IL-5 and VEGF play an important role in the occurrence and development of asthma in children with mycoplasma pneumonia pneumonia.