摘要
糖尿病肾病(diabetic nephropathy,DN)是糖尿病(diabetes mellitus,DM)晚期微血管并发症之一,是DM患者的重要死亡原因。而DN的发病机理如同其他DM微血管并发症一样尚未完全阐明。建立合适的DN动物模型是研究DN的发病机理和干预手段的基础。本文综述DN动物模型的研究进展,分析诱发性、自发性及转基因3类动物模型的优缺点,并对各模型致病机理、疾病表现、肾脏病理改变以及应用现状进行了详细的阐述,为研究DN的发病机理、防治及相关药物开发提供参考。
Diabetic nephropathy（DN） is one of late diabetic microvascular complications and is the leading cause of the death of diabetics. But the etiopathogenesis of the DN and the diabetic mierovaseular complications haven＇t been elucidated. To study the etiopathogenesis and the interventions of DN, the establishment of an appropriate animal model is necessary. This paper reviewed the research progress of DN animal models, analyzed the advantages and disadvantages of experimental, spontaneous and transgenic animal models, and introduced the pathogenic mechanism, manifestations of the disease, renal pathological changes and current application of each model. This paper will provide reference for the research of the DN pathogenesis and prevention, and the development of related drugs
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2014年第1期112-115,共4页
Traditional Chinese Drug Research and Clinical Pharmacology
关键词
糖尿病肾病
动物模型
Diabetic nephropathy
Animal models
