血清骨保护素与2型糖尿病及合并冠心病的关系

The relationship between osteoprotegerin and type 2 diabetes mellitus with or without coronary artery disease

目的探讨血清骨保护素(OPG)与2型糖尿病及合并冠心病的关系。方法选择健康个体、2型糖尿病患者及2型糖尿病合并冠心病患者各30例。用ELISA方法测定OPG,生化法测定空腹血糖(FPG)及糖化血红蛋白(HbA1c),免疫化学发光法测定空腹胰岛素(FINS),计算胰岛素敏感指数(ISI)及胰岛素抵抗指数(HOMA-IR),并观察组间各指标的变化。结果 2型糖尿病组及合并冠心病组血清OPG、FPG、HbA1c、HOMA-IR明显高于对照组(P均<0.01),ISI明显低于对照组(P<0.01)。2型糖尿病合并冠心病组FINS显著高于对照组(P<0.05)。2型糖尿病组HbA1c明显高于2型糖尿病合并冠心病组(P<0.01)。结论 2型糖尿病及其合并冠心病患者血清OPG水平、血糖、胰岛素及HOMA-IR明显增高,2型糖尿病患者冠心病发生与血清OPG、血糖、胰岛素升高以及胰岛素抵抗有关,OPG作为心血管疾病的预测因子可能与胰岛素的影响有关。

Objective To investigate the relationship between osteoprotegerin （OPG）and type 2 diabetes mellitus（T2DM） with or without coronary artery disease （CAD）.Methods The healthy individuals（control group）, T2DM patients with or without CAD with 30 cases in each group were selected respectively .ELISA was used for deter-mination of OPG, biochemistry method for fasting blood glucose （FPG） and glycosylated hemoglobin （HbA1c）, im-munochemical chemiluminescence for fasting insulin （ FINS） , insulin sensitivity index （ ISI） and insulin resistance in-dex（HOMA-IR） were calculated,and the data in all groups were observed .Results OPG, FPG,HbA1c and HOMA-IR in groups of T2DM with or without coronary artery disease were obviously higher than those in control group （ P〈0.01）,and ISI was lower than that in control group （P〈0.01）.FINS in the group of T2DM with CAD was higher than that in control group（P〈0.05）.HbA1c in the group of T2DM was higher than that in the group of T2DM with CAD（ P〈0.01 ） .Conclusion The level of serum OPG ,blood glucose ,insulin and insulin resistance index in groups of T2DM with or without CAD increase obviously .Development of CAD in T2DM patients relate to the increased level of OPG,blood glucose ,insulin and insulin resistance .OPG as a risk predictor of cardiovascular disease may be related to the effects of insulin .