原发性甲状腺功能减退合并脑梗死患者的幽门螺旋杆菌感染分析

Analysis on helicobacter pylori infection of patients with primary hypothyroidism combined with cerebral infarction

目的分析原发性甲状腺功能减退(原发性甲减)合并脑梗死患者的幽门螺旋杆菌(Hp)感染情况,并探讨其可能的作用机制。方法选择82例原发性甲减合并脑梗死患者,根据Hp检测结果分成Hp阳性组(50例)和Hp阴性组(32例),对脑梗死的一些高危因素进行对比分析。结果 Hp阳性组的C-反应蛋白(CRP)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)高于Hp阴性组(P<0.01),而高密度脂蛋白胆固醇(HDL-C)低于Hp阴性组(P<0.05)。结论 Hp感染可能是原发性甲减患者发生脑梗死的危险因素之一。

Objective To evaluate the relationship of helicobacter pylori （ Hp） infection with cerebral infarc-tion in patients with primary hypothyroidism and analyze of the possible mechanism .Methods Eighty-two cases with primary hypothyroidism were divided into two groups according to the results of Hp：Positive Hp group （ n=50 ） and negative Hp group （ n=32 ） .The high risk factor of cerebral infarction were detected .Results Positive Hp group showed higher C-response protein（CRP） and TG and LDL-C than the negative Hp group（P〈0.01）, but lower HDL-C than the negative Hp group （ P〈0.05 ） .Conclusion Results showed that Hp infection may be a risk factor of cer-ebral infarction in primary hypothyroidism .