复发急性格林-巴利综合征临床分析

Clinical analysis of recurrent Guillain-Barre syndrome

目的探讨复发急性格林-巴利综合征(GBS)的临床特点。方法选择收治的3例复发GBS的患者(均符合Asbury 1990年诊断标准),分析其诱因、发病过程、临床表现、肌电生理检查、脑脊液检查、治疗及预后等。结果经治疗3例中1例3个月恢复正常,1例5个月恢复正常,1例遗留肢体肌力减弱。结论复发GBS有发病急、进展快、病程长及病情重等特点,治疗目前仍以免疫球蛋白及血浆置换等方法为主,临床预后相对较好,但对于反复发作的GBS,亦可以遗留严重的神经功能损害。

Objective To explore the clinical feature of recurrent Guillain-Barre syndrome（GBS）.Methods The predisposition , pathogenetic process , clinical manifestations , electrophysiologic examination , cerebrospinal fluid examination , therapeutic process and prognosis were analyzed in 3 patients with recurrent GBS in accord with diagnos-tic criteria of Asbury in 1990 .Results Complete recovery was abstained in one patient 3 months after treatment , and in one patient 5 months after treatment , and mild decrease of limbs muscle strength was left in one patient .Conclu-sion Recurrent GBS was characterized by acute onset ,rapid deterioration ,long and critical course .The main treat-ment included intravenous immunoglobulin or plasma exchange .Clinical prognosis was relatively good .But severe nerve function damage maybe leaved in the patients with repeated relapse of GBS .