血浆抗凝血酶Ⅲ、纤维蛋白原浓度与冠状动脉病变严重程度的关系

目的探讨血浆抗凝血酶Ⅲ、纤维蛋白原（fibrinogen，Fbg）浓度与冠状动脉病变严重程度的关系。方法冠心病患者137例，按Gensini评分分为三组，A组（〈20分组）、B组（20．40分组）、C组（〉40分组），另对照组患者131例。分别比较各组间外周血血浆抗凝血酶Ⅲ、纤维蛋白原浓度。结果冠心病患者的血浆抗凝血酶Ⅲ浓度明显低于对照组（P〈0．01），纤维蛋白原的浓度明显高于对照组（P〈0．01），且不同Gensini积分组血浆抗凝血酶Ⅲ、纤维蛋白浓度之间差异有统计学意义（P〈0．01）。结论血浆抗凝血酶Ⅲ、纤维蛋白原浓度与冠脉病变严重程度有密切关系，且可以预测患者冠状动脉病变的严重程度。

Objectives To study the relationship of the concentration of plasma antithrombin -Ⅲ and fibrinogen and the severity of the coronary artery lesions. Methods The study population included 268 patients who had undergone coronary angiography in the first affiliated hospital of the Soochow University between Juanary 2012 to December 2012.The patients were divided into the CHD group （ 137eases ） and the normal control group （ 131 cases ） depending on the Results of the coronary angiography.According to the Gensini score we divided the CHD group into the groups： A group （ 〈20 points ） , B group （ 20-40 points ） , and C group （〉40points） ： The concentration of plasma antithrombin -Ⅲ and fibrinogen were compared among groups. Results The mean levels of plasma antithrombin -Ⅲ in the CHD group were obviously lower than that in the normal control group （ P〈0.01 ） .The mean levels of plasma fibrinogen in the CHD group were obviously higher than that in the normal control group （ P〈0.01 ） .there are also staftsticallysignifican difference among the different groups of Gensini scores （ P〈0.01 ） . Conclusions The cocentration of plasma antithrombin -Ⅲ and fibrinogen are closely related with the severity of coronary artery lesions, and They can be a predictor of the severity of coronary artery lesions.