糖化血红蛋白在早孕期糖尿病筛查中的意义

目的：探讨糖化血红蛋白（HbA1c）在早孕期糖尿病（GDM）筛查中的意义。方法正常组120例、糖耐量异常组59例及糖尿病组78例，在妊娠20周时分别进行空腹血糖（FPG）、75g葡萄糖耐量实验（OGTT）和HbA1c测定。结果糖尿病组FPG，OGTT，HbA1c水平均高于正常组（P〈0.01），HbA1c在糖耐量异常组及糖尿病组中的阳性率分别为96.7%、98.7%。结论 HbA1c在GDM筛查中的诊断效率明显高于FPG和OGTT，可作为临床GDM早孕期筛查诊断的指标。

Objective To investigate the glycosylated hemoglobin（HbA1c）in early stage of gestational diabetes mellitus （GDM）screening significance. Methods In 120 normal subjects,59 patients with abnormal glucose tolerance group and diabetes group 78 cases at 20 weeks of gestation were fasting blood glucose（FPG）,75g glucose tolerance test（OGTT）and glycosylated hemoglobin（HbA1c）determination. Results The diabetic group FPG,OGTT,HbA1c levels were higher than normal group （P〈0.01）,The positive rate of HbA1c in the impaired glucose tolerance group and diabetes group were 96.7%,98.7%. Conclusion The diagnostic efficiency of HbA1c in screening of GDM was significantly higher than that in FPG and OGTT,can be used as a clinical diagnosis of GDM in first trimester screening index.