摘要
采用差示扫描量热法(DSC),根据DSC曲线利用纯度分析软件测定草酸艾司西酞普兰的纯度。对实验条件进行了优化,升温速率为4.0 K/min,称样量为2~3.2 mg。测得草酸艾司西酞普兰的纯度为99.17%,相对标准偏差为0.05%(n=6)。该法测定结果与非水滴定法测定结果(99.24%)基本一致。差示扫描量热法可用于测定草酸艾司西酞普兰纯度,方法操作简便、结果准确。
The differential scanning calorimetry (DSC) technique was used to determine the purity of escitalopram oxalate, according to the DSC curve and by using the purity analysis software. The experimental conditions were optimized, the heating rate was 4.0 K/min and the sample mass was 2-3.2 mg. The purity result determined by DSC method was 99.17%, RSD was 0.05%(n=6). The result was consistent with the result (99.24%) determined by the non-aquseous trirtation method. The DSC method is accurate and simple for the determination of escitalopram oxalate purity.
出处
《化学分析计量》
CAS
2014年第1期57-60,共4页
Chemical Analysis And Meterage
关键词
草酸艾司西酞普兰
纯度
差示扫描量热法
非水滴定法
escitalopram oxalate
purity
differetial scanning calorimetry
non-aqueous trirtation method