皮下注射低分子肝素时不同推注时间对皮下出血的影响

Effect of injection duration on bruising associated with subcutaneous low molecular weight heparin

目的比较低分子肝素注射过程中3种不同推注时间对皮下出血发生率及出血面积的影响,找出有效的推注方法,以减少皮下出血的发生,减小出血面积。方法选择接受低分子肝素皮下注射治疗的患者86例,采用自身对照法,每例患者分别接受3种不同推注时间的皮下注射:方法A:推注时间10s;方法B:推注时间30s;方法C:推注时间为10s,停留10s之后拔针。观察3种方法所致皮下出血发生率和出血面积。结果低分子肝素皮下注射过程中,方法B、C与方法A比较,能明显降低注射部位皮下出血的发生率及减小出血面积。结论临床低分子肝素注射过程中,可使用推注时间为30s或推注时间10s,停留10s再拔出针头的方法,减少患者在接受低分子肝素治疗过程中皮下出血的发生。

Objective To investigate the effect of three different injection durations on the incidence and area of bruising associated with subcutaneous low molecular weight heparin. Methods A self-controlled study was conducted on 86 patients receiving subcutaneous injection of low molecular weight heparin with different injection durations：10s（group A）,30s（group B）,10s and waiting for 10s before withdrawal（group C）. The incidence and area of bruising were measured at 48h after injection. Results The incidence and area of bruising was significantly lower or smaller in group B and group C compared with group A. Conclusion It is suggested to inject 30s or 10s but waiting 10s before withdrawal to reduce the incidence of bruising associated with subcutaneous low molecular weight heparin.