阿托伐他汀对老年男性急性冠脉综合征患者血清铁蛋白水平的影响

Effect of atorvastatin on serum ferritin levels in elderly male patients with acute coronary syndrome

目的：探讨应用阿托伐他汀对老年男性急性冠脉综合征（ACS）患者血清铁蛋白（SF）水平的影响及其临床意义。方法将沧州市人民医院心内科收治的120例老年男性ACS患者按随机原则分为治疗组和对照组，每组60例。两组均进行冠心病的规范治疗，治疗组在此基础上加用阿托伐他汀20 mg，每日1次口服，治疗1个月后，测定两组治疗前后SF及血脂水平的变化。结果两组治疗后患者的总胆固醇（TC）、低密度脂蛋白（LDL）及SF水平均较治疗前明显下降；治疗组治疗后三酰甘油（TG）降低、高密度脂蛋白（HDL）明显升高，对照组治疗后TG升高、HDL降低；但治疗组和对照组治疗后SF、TC、TG、HDL及LDL水平比较差异均有统计学意义〔S F（μg/L）：174.33＆#177;99.87比255.66＆#177;100.34，TC（mmol/L）：4.23＆#177;0.60比5.15＆#177;0.56， TG（mmol/L）：1.98＆#177;0.64比2.00＆#177;1.03，HDL（mmol/L）：1.13＆#177;0.14比1.09＆#177;0.22，LDL（mmol/L）：2.45＆#177;0.33比3.35＆#177;0.50，P＜0.05或P＜0.01〕。结论老年男性ACS患者入院时SF水平明显高于正常水平，经规范阿托伐他汀治疗后，血脂和SF水平均明显降低，减轻了SF对心肌的损伤，降低了再发急性冠脉事件的风险。

Objective To explore the effect of atorvastatin application on serum ferritin（SF）levels in elderly male patients with acute coronary syndrome（ACS）and its clinical significance. Methods 120 elderly male patients treated in Department of Cardiology in Cangzhou People＆#39;s Hospital were randomly divided into treatment group and control group（60 cases in each group）. All the patients in the two groups took the standard treatment of coronary heart disease,and the patients in treatment group were additionally given atorvastatin 20 mg orally,once-daily for 1 month. After 1 month of treatment,the changes in SF and lipid levels before and after treatment were determined. Results The total cholesterol（TC）,low density lipoprotein（LDL）and SF levels of the two groups after treatment were significantly decreased compared with those before treatment. After treatment,triacylglycerol （TG）was decreased,and high-density lipoprotein（HDL）was increased significantly in treatment group,while in the control group,after treatment TG was increased and HDL was decreased. Compared between treatment and control groups after treatment,the differences in SF,TC,TG,HDL and LDL levels were statistically significant〔SF（μg/L）：174.33＆#177;99.87 vs. 255.66＆#177;100.34,TC（mmol/L）：4.23＆#177;0.60 vs. 5.15＆#177;0.56,TG（mmol/L）：1.98＆#177;0.64 vs. 2.00＆#177;1.03,HDL（mmol/L）：1.13＆#177;0.14 vs. 1.09＆#177;0.22,LDL（mmol/L）：2.45＆#177;0.33 vs. 3.35＆#177;0.50,P＆lt;0.05 or P＆lt;0.01〕. Conclusion In elderly male hospitalized patients with ACS,the level of SF is significantly higher than normal,after atorvastatin specification treatment,the blood fat and SF levels are significantly lower,thus the SF inducing myocardial damage may be reduced and the risk of recurrence of acute coronary events can be decreased.