期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

肢体缺血预处理对止血带性心肌损伤的保护作用 被引量：9

下载PDF
导出
摘要 止血带可减少术野出血,保证手术野的清晰而成为骨科常用的设备.但长时间止血带后又必然使肢体产生缺血-再灌注损伤（limbs ischemia reperfusion,LIR）,主要表现细胞因子的释放、中性粒细胞粘附后释放毒素介质及氧自由基的形成.一方面影响了局部组织功能,另一方面产生全身炎症反应,累及心肺等器官[1].特别是心血管系统的损伤最为重要,常表现为应激性心肌缺血和心功能损伤等[2].已有研究发现,肢体缺血预处理能有效启动内源性心肌保护作用,但这些研究主要讨论肢体缺血预处理对心肌缺血-再灌注的保护[3～5].本研究旨在探讨肢体缺血预处理是否能减轻下肢缺血-再灌注所致的心肌损伤.
作者 刘平 吴周全 李立
机构地区 南京医科大学附属常州第二人民医院麻醉科
出处 《临床麻醉学杂志》 CAS CSCD 北大核心 2014年第1期89-90,共2页 Journal of Clinical Anesthesiology
关键词 肢体缺血预处理 心肌保护作用 心肌损伤 止血带 缺血-再灌注损伤 心肌缺血-再灌注 ISCHEMIA 中性粒细胞粘附
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献7

  • 1Wakai A,Wang JH,Winter DC,et al;Tounriquet-induced sys-temic inflammatory reponse in extremity surgery.J Trauma,2001,51(5).922-926.
  • 2Lu X,Hamilton JA,Shen J,et al.Role of tumor necrosisfactor-alpha in myocardial dysfunction and apoptosis duringhindlimb ischemia and reperfusion.Crit Care Med,2006,34(2):484-491.
  • 3Oxman T,Arad M,Klein R,et al.Limb ischemia preconditionsthe heart against reperfusion tachyarrhythmia.Am J Physiol.1997,273(4):1707-1712.
  • 4Wolfrum S,Schneider K,Heidbreder M,et al.Remote precondi-tioning protects the heart by activating myocardial PKCepsilon-isoform.Cardiovasc Res,2002,55(3):583-589.
  • 5刘小军,易善永,廖斌,邓明彬,陈圣杰,王峰.肢体缺血预处理对心脏瓣膜置换术心肌保护作用的研究[J].心血管康复医学杂志,2007,16(4):347-349. 被引量：7
  • 6Yassin MM,Harkin DW,Barros AA,et al.Lower limbischemia-reperfusion injury triggers a systemic inflammatoryresponse and multiple organ dysfunction.World J Surg,2002,26(1):115-121.
  • 7韩莉莉,沈晓丽.髓过氧化物酶及其基因多态性的研究进展[J].医学综述,2007,13(17):1288-1290. 被引量：11

二级参考文献29

  • 1刘小青,魏经汉.犬肢体缺血预处理对心肌的影响[J].中国循环杂志,1996,11(9):557-560. 被引量：5
  • 2Tatyana O,Michael A,Rodica K,et al.Limb ischemia preconditions the heart against reperfusion tachyarrhythmia[J].J Am Physiol,1997,273:H1707-1712.
  • 3Tang ZL,Dai W,Li YJ,et al.Involvement of capsaicin-sensitive sensory nerves in early and delayed cardioprotection induced by a brief ischaemia of the intestine[J].Naunyn Schmiedebergs Arch Pharmacol,1999,360 (3):358-365.
  • 4Gunaydin B,Cakici I,Soncul H,et al.Does remote orgen ischemia trigger cardiac preconditioning during coronary artery surgery?[J].Phamacol Res,2000,41 (4):493-496.
  • 5Wolfrum S,Schneider K,Heidbreder M,et al.Romote preconditioning protects the heart by activating myocardial PKC epsilon-isoform[J].Cardiovasc Res,2002,55 (3):583.
  • 6Anderson E,Hellman L,Gullberg U,et al.Albumin mediates the transcytosis of myeloperoxidase by means of caveolae in endothelial cells[J].J Biol Chem,1998,273(20):4747-4753.
  • 7Piedrafita FJ,Molander RB,Vansant G,et al.An Alu element ifn the myeloperoxidase promoter contains a composite SP1-thyroid hormone retinoic acid responseelement[J].J Biol Chem,1996,271(24):14412-14420.
  • 8Rutgers A,Heerinqa P,Giesen JE,et al.Neutrophil myeloperoxidase activity and the influence of two single-nucleotide promoter polymorphisms[J].Br J Haematol,2003,123(3):536-538.
  • 9Nauseef WM,Brigham S,Cogley M.Hereditary myeloperoxidase deficiency due to a missense mutation of arginine 569 to trypophan[J].J Biol Chem,1994,269(2):1212-1216.
  • 10Austin GE,Lam L,Zaki SR,et al.Sequence comparison of putative regulatory DNA of the 5'flanking region of the myeloperoxidase gene in normal and leukemic bone marrow cells[J].Leukemia,1993,7(9):1445-1450.

共引文献16

同被引文献73

  • 1Lian-Yue Guan,Pei-Yao Fu,Pei-Dong Li,Zhuo-Nan Li,Hong-Yu Liu,Min-Gang Xin,Wei Li.Mechanisms of hepatic ischemia-reperfusion injury and protective effects of nitric oxide[J].World Journal of Gastrointestinal Surgery,2014,6(7):122-128. 被引量：44
  • 2蔡海鸥,张伟明,陆廷仁.全膝关节置换术后肌力训练对膝关节功能的影响[J].中华物理医学与康复杂志,2007,29(3):178-180. 被引量：11
  • 3Estebe JP, Davies JM, Richebe P. The pneumatic tourniquet: mechanical,ischemia-reperfusion and systemic effects. Eur J Anaesthesiol, 2011,28 ( 6 ) : 404-411.
  • 4Lucchinetti E, Ambrosio S, Aguirre J, et al. Sevoflarane in- halation at sedative concentrations provides endothelial pro- tection against ischemia-reperfusion injury in humans. Anes- thesiology, 2007,106(2) : 262-268.
  • 5Yassin MM, Harkin DW, Barros ErSa AA, et al. Lower limb ischemia-reperfusion injury triggers a systemic inflammatory response and roultiple organ dysfunction. World J Surg, 2002, 26(1) : 115-121.
  • 6Murry CE,Jennings RB, Reimer KA. Preconditioning with is- chemia: a delay of lethal cell injury in ischemic myocardium. Circulation, 1986,74(5) : 1124-1136.
  • 7Ismaeil MS, Tkachenko I, Hickey RF, et al. Colchicine in- hibits isoflurane-induced preconditioning. Anesthesiology, 1999, 91(6) : 1816-1822.
  • 8Caries M, Dellamonica J, Roux J, et al. Sevoflurane but not propofol increases interstitial glyeolysis metabolites availabili- ty during tourniquet-induced ischaemia-reperfusion. Br J An- aesth, 2008,100(1) : 29-35.
  • 9Lucchinetti E,Ambrosio S, Aguirre J, et al. Sevoflarane inha- lation at sedative concentrations provides endothelial protec- tion against ischemia-reperfusion injury in humans. Anesthe- siology, 2007,106(2) : 262-268.
  • 10李进,袁世荧,丰新民,姚尚龙.舒芬太尼延迟预处理对兔心肌缺血再灌注损伤的影响[J].中华麻醉学杂志,2009,29(8):692-695. 被引量：28

引证文献9

二级引证文献38

临床麻醉学杂志
2014年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部