补肺益肾法治疗特发性肺间质纤维化所致慢性呼吸衰竭

Clinical Study of Bufei Yishen Treatment of Idiopathic Pulmonary Interstitial Fibrosis Caused by Chronic Respiratory Failure

目的:探讨补肺益肾法治疗特发性肺间质纤维化(idiopathic pulmonary fibrosis,IPF)所致慢性呼吸衰竭的临床效果。方法:本研究将收治的特发性肺间质纤维化所致慢性呼吸衰竭患者按照随机数字表法随机分为研究组和对照组,其中对照组采取针对性的常规治疗措施,研究组在对照组上述治疗方案的基础上应用具有补肺益肾功效的中药进行联合治疗,比较两组患者的临床治疗效果及主要血气指标。结果:研究组患者的总有效率(90.32%)明显高于对照组(67.74%)(P<0.05)。两组患者在治疗后动脉血氧饱和度(SaO2)、血氧分压(PaO2)、血二氧化碳分压(PaCO2)、碳酸氢根(HCO3)、pH等血气主要指标均较治疗前明显改善,但是研究组的改善程度明显优于对照组(P<0.05)。结论:在西药常规基础治疗的同时加用补肺益肾方治疗,IPF所致肺肾气虚型慢性呼吸衰竭疗效肯定,可有效改善患者的肺功能,比单纯西医治疗具有一定优势,是治疗慢性阻塞性肺疾病安全有效的方法。

Objective ： To investigate the clinical effect of Bufei Yishen treatment of idiopathic pulmonary interstitial fibrosis caused by chronic respiratory failure. Method： In this study, idiopathic pulmonary interstitial fibrosis caused by chronic respiratory failure patients were randomly divided into study group and control group. The control group took the routine treatment measures. The study group was given Bufei Yishen traditional Chinese medicine and therapy method above. The clinical efficacy and blood gas index were compared between two groups. Result： The total efficiency of study group （90.32%） was significantly higher than those in control group （67.74%） （P 〈 0.05）. The main index of patients in the two groups after treatment SaO2, PaO2, PaCO2, HCO3, pH and blood gas were significantly improved after treatment, but the study group improved significantly better than the control group （P 〈 0.05 ）. Conclusion： While the conventional western medicine foundation treatment with Bufei Yishen decoction, curative effect of IPF induced lung and kidney deficiency type chronic respiratory failure, which can effectively improve pulmonary function. It has certain advantages than the pure western medicine treatment, and is the treatment of chronic obstructive pulmonary disease is safe and effective.