微管不稳定蛋白和Endoglin在大肠癌组织中的表达

Significance and expression of stathmin and endoglin in colorectal carcinoma

目的 探讨微管不稳定蛋白（Stathmin）和Endoglin标记的微血管密度计数（MVD）在大肠癌中的表达及其与临床病理学参数之间的关系.方法 收集46例大肠癌患者手术切除的肿瘤组织和癌旁组织,运用免疫组织化学法检测Stathmin和Endoglin标记的MVD在组织中表达水平.结果 Stathmin大肠癌组织的表达率为69.57％ （32/46）,明显高于癌旁组织表达率[34.78％ （16/46）],两者差异有统计学意义（P＜0.01）,Stathmin表达水平与大肠癌组织学分化程度、浸润深度、TNM分期、淋巴结转移明显相关（P＜0.05）;Endoglin标记的MVD大肠癌组织的表达强度为（68.27±5.66）个,明显高于癌旁组织的表达强度[（41.51±4.52）个],两者差异有统计学意义（P＜0.01）;Endoglin标记的MVD表达强度与大肠癌浸润深度、TNM分期、淋巴结转移明显相关（P＜0.05）.结论 联合检测Stathmin和Endoglin有助于判断大肠癌临床生物学行为.

Objective To analyze the relationship between the expression of Stathmin and endoglin-marked microvessel density （MVD） and clinicopathological features of colorectal carcinoma.Methods Immunohistochemistry was used to detect the expression levels of Stathmin and MVD marked with endoglin in 46 cases of human colorectal carcinoma tissues and non-cancerous adjacent colorectal tissues.Results The expression rate of Stathmin was 69.57% （32/46） in colorectal carcinoma tissues,and 34.78%（16/46） in non-cancerous adjacent colorectal tissues （P 〈0.01）.The expression of Stathmin was related to histologic grade,serosa invasion,TNM stage and lymph node metastasis in colorectal carcinoma （P 〈0.05）.The expression of MVD marked with endoglin was （68.27 ± 5.66） in colorectal carcinoma tissues,and （41.51 ±4.52） in non-cancerous adjacent colorectal tissues （P 〈0.01）.The expression of MVD was related to serosa invasion,TNM stage and lymph node metastasis （P 〈 0.05）.Conclusion The combined detection of Stathmin and endoglin may be used to determine the biological behaviors of colorectal carcinoma.