硫酸氢钠催化合成氯乙酸异丙酯

Catalytic Synthesis of iso-propyl Chloroacetate with Sodium Bisufate

硫酸氢钠能够代替硫酸用于酯化反应中。当 0 .5g一水硫酸氢钠作为催化剂 ,1 5ml环己烷为溶剂 ,由 0 .1mol氯乙酸和 0 .2mol异丙醇回流分水 2 .5h ,氯乙酸异丙酸收率可达 83%

Sodium bisulfate can be used as catalyst for the esterification instead of sulphuric acid.Isopropyl chloroacetate was synthesis by 0.1 mol chloroacetic acid with 0.2 mol isopropyl alcohol,0.5 g sodium bisulfate monohydrate (NaHSO 4 ·H 2 O) as catalyst,15 ml cyclohexane as solvent,reflaxing and water segrating for 2.5 h,the yield of ester could reach 83%.