草酸艾司西酞普兰加心理干预对老年冠心病并发抑郁症的疗效分析

The curative effect analysis to treat depressive disorder in elderly coronary heart disease with Escitalopram Oxalate and psychological intervention

目的观察草酸艾司西酞普兰加心理干预治疗老年冠心病并发抑郁症患者的效果。方法冠心病伴发抑郁障碍患者54例,将其分为治疗组(30例)与对照组(24例)。治疗组给予草酸艾司西酞普兰治疗和心理干预,起始剂量5 mg/d,最高日剂量为20 mg,总疗程为6周;对照组采用常规药物治疗。治疗6周评定疗效,同时观察不良反应。结果治疗组患者6周后焦虑自评量表、抑郁自评量表、汉密顿抑郁量表评分、抑郁情绪改善程度和同型半胱氨酸、超敏C反应蛋白下降程度、临床总有效率均优于对照组(P<0.01或P<0.05)。结论草酸艾司西酞普兰治疗加上心理干预对冠心病抑郁症患者疗效好,且起效快,副作用少,安全性高。

Objective To observe and analyze the curative effect of Escitalopram Oxalate and psychological interven tion on depression accompanying with coronary heart disease. Methods 54 cases accompanied with depression were di vided into two groups： the treatment group （n = 30） and control group （n = 24）. The treatment group was given Esci talopram Oxalate at an initial dose of 5 mg （not more than 20 rag） a day and positive psychological intervention. The total period of treatment was 6 weeks. The control group was given conventional drugs. The effects were evaluated after 6 weeks, and adverse reactions were observed. Results After treating for 6 weeks, scores of the anxiety index, the de pression index, HAMD, the situation of improved depression, the degree of decrease with Hcy, bs-CRP and clinical to- tal efficiency of the treatment group were significantly better than those of the control group （P 〈 0.01 or P 〈 0.05）. Conclusion Eseitalopram Oxalate is effective and safe in the treatment of depression accompanying with coronary heart disease. It can be taken conveniently and has the characteristics of faster onset of action, better compliance, with fewer side effects.