N末端C型利尿钠肽前体对高血压患者预后判断的影响

Influence of N-terminal C-type natriuretic peptide precursor on prognosis of patient with hypertension

目的探讨N末端C型利尿钠肽前体(NT-proCNP)对高血压患者预后判断的影响。方法选取入选体检人员405例,其中健康对照组90例,高血压组315例。随访1年8个月高血压组中的297例分为高血压并发症亚组49例,高血压无并发症亚组248例。分别测定两组及两亚组的NT-proCNP水平。结果高血压组的NTproCNP为(5.4±1.1)pmol/L,高于健康对照组的(4.3±0.5)pmol/L,差异有统计学意义(P<0.05)。高血压并发症亚组入选时的NT-proCNP为(6.0±1.1)pmol/L,高于高血压无并发症亚组的(5.2±0.8)pmol/L,差异有统计学意义(P<0.05)。结论测定NT-proCNP水平可判断高血压患者的预后。

Objective To investigate influence of N-terminal C-type natriuretic peptide precursor on prognosis of patient with hypertension.Methods 405 cases of medical personnel were selected,including 90 cases of healthy control group and 315 cases of hypertension group.297 patients with hypertension were followed up for 1 year and 8 months and divided into hypertension with complication subgroup （49 cases） and hypertension without complication subgroup （248 cases）.The levels of NT-proCNP in each group and each subgroup was measured respectively.Results NT-proCNP of hypertension group was（5.4±1. 1）pmol/L,higher than that of healthy control group（4.3±0.5）pmol/L,with statistical difference（P〈0.05）.NT-proCNP of hypertension with complication subgroup was（6.0±1.1）pmol/L,higher than that of hyperten- sion without complication subgroup（5.2±0.8）pmol/L,with statistical difference（P〈0.05）.Conclusion Determination of NT- proCNP level can determine the prognosis of patient with hypertension.