心钠肽辅助治疗急性或慢性心力衰竭的临床研究

Clinical research of atrial natriuretic peptide in adjuvant therapy of acute or chronic heart failure

目的 探讨心钠肽辅助治疗急性或慢性心力衰竭的临床效果.方法 选取本院2011年2月～2013年2月诊治的急性或慢性心力衰竭患者117例,随机分为两组,58例患者行安慰剂治疗为对照组,59例患者行心钠肽辅助治疗为观察组,比较两组患者的尿量改变情况、血气指标改变情况、呼吸困难改善情况.结果 治疗后,两组患者尿量均明显增加,观察组尿量明显高于对照组,呼吸困难改善情况明显好于对照组,差异有统计学意义（P＜0.05）.两组患者血氧分压均有所升高,血二氧化碳分压均有所降低,观察组血氧分压高于对照组,血二氧化碳分压低于对照组,差异无统计学意义（P＞0.05）.结论 心钠肽辅助治疗急性或慢性心力衰竭可明显改善患者的呼吸状况和尿量情况.

Objective To investigate clinical effect of atrial natriuretic peptide in adjuvant therapy of acute or chronic heart failure. Methods 117 patients with acute or chronic heart failure were selected in hospital from February 2011 to February 2013,who were randomly divided into two groups.58 patients treated with placebo as control group,59 patients treated with atrial natriuretic peptide as observation group.Changes of urine volume,blood gas index,dyspnea improve- ment were compared between two groups. Results Urine volume increased significantly in two groups after treatment, the urine volume in observation group was significantly higher than that of the control group,the dyspnea improvement in observation group was significantly better than control group,the difference was significant （P〈0.05）.Partial pressure of oxygen increased,while partial pressure of carbon dioxide decreased in two groups,the partial pressure of oxygen in observation group was higher than that of the control group,the partial pressure of carbon dioxide in observation group was lower than control group,the difference was not significant （P〉0.05）. Conclusion Atrial natriuretic peptide can sig- nificantly improve respiratory conditions and urine volume in adjuvant therapy of acute or chronic heart failure.