住院患者肠球菌属感染的临床分布及耐药性分析

Distribution and drug resistance of Enterococcusisolated from inpatients

目的了解住院患者肠球菌属感染的临床分布及对抗菌药物的耐药性,为临床治疗提供依据。方法回顾性分析2011-2012年各类临床标本分离出的肠球菌属分布特点及药敏结果。结果 735株肠球菌属中粪肠球菌427株、屎肠球菌268株、鹑鸡肠球菌24株、鸟肠球菌15株、坚忍肠球菌1株,分别占58.1%、36.5%、3.3%、2.0%、0.1%;肠球菌属主要分离自尿液361株、胆汁108株、分泌物77株,分别占49.1%、14.7%、10.5%;粪肠球菌对喹奴普汀/达福普汀耐药率最高,为99.8%,其次是克林霉素、四环素,分别为98.8%、82.2%,屎肠球菌对莫西沙星耐药率最高,为85.8%,其次是氨苄西林、青霉素,分别为85.4%、85.1%。结论肠球菌属在临床分布和耐药性有较大差异,临床治疗应以药敏试验为依据。

OBJECTIVE To explore the distribution and drug resistance of Enterococcus isolated from inpatients, so as to provide the evidence for clinical treatment. METHODS The distribution and drug resistance of Enterococcus isolated from various clinical specimens from 2011 to 2012 were analyzed retrospectively. RESULTS Totally 735 strains of Enterococcus were isolated from clinical specimens, including 427 strains of E. faecalis（58.1%）, 268 strains of E. faecium（36.5%）, 24 strains of E. gallinarurn（3.3%）, 15 strains of E. avium（2.0%）, 1 strain of E. durans（0. 1%）. The strains were mainly isolated from urinary（361 strains, accounting for 49. 1%）, bile（108 strains, accounting for 14. 7%）, discharge（77 strains, accounting for 10. 5%）. E. faecalis had the highest resistance rate to quinupristin/ dalfopristin （99.8%）, followed by clindamyein 98.8%, tetracycline 82.2%. E. faeciurn had the highest resistance rate to moxifloxacin （85. 8%）, followed by ampicillin 85. 4%, penicillin 85.1%. CONCLUSION Because of the obvious difference in the distribution and drug resistance of Enterococcus, the clinical treatment should be based on susceptibility test results.