应用抗菌药物预防产褥感染的效果研究

Effect research on puerperal infection prenvention with antimicrobial agents

目的评价临床药师干预使用抗菌药物预防产褥感染的效果研究,以有效地预防产褥感染的发生。方法选取医院2011年6-12月及2012年6-12月住院分娩产妇作为研究对象,将2012年的病例设为干预组,2011年的病例设为对照组,每组各150例;收集患者的基本信息及使用抗菌药物的适应证、用药品种、用药时机、给药疗程、联合用药等,找出住院分娩产妇预防使用抗菌药物存在的主要问题,并针对存在问题进行干预。结果干预组经过临床药师对分娩产妇围手术期预防性应用抗菌药物进行干预,各项指标使用抗菌药物合理率有所提高,差异有统计学意义(P<0.05);干预组患者联合用药的频次较对照组明显下降,由57.33%下降至21.33%,差异有统计学意义(P<0.05);预防用药时间及住院时间也分别下降至(1.98±0.93)、(11.43±2.93)d;住院分娩产妇的产褥感染率由13.33%下降至2.67%。结论通过临床药师对使用抗菌药物预防产褥感染的积极干预,有效地促进了抗菌药物的合理使用,使住院分娩产妇的产褥感染率明显下降。

OBJECTIVE To evaluate the effect of puerperal infection prenvention with antimicrobial agents under the intervention of pharmacists, so as to prevent puerperal infections. METHODS A total of 150 pregnant women were chosen to be analyzed as control group from Jun. to Dec. 2011, and another 150 pregnant women as treatment group from Jun. to Dec. 2012. The patients＇ basic information, and indication, varieties, medication time, course of treatment, combination of antimicrobial agents were recorded to find the problems of antimicrobial agents use on prevention of puerperal infections and take intervention measures to prevent the problems. RESULTS After the intervention of pharmacists in treatment group using antimicrobial agents to prevent puerperal infections, the application rate of antimicrobial agents was higher and the differences were statistically significant（P〈0.05）. The frequency of using combination of antimicrobial agents in treatment group was declined comparing control group from 57.33 % to 21.33 %, and the difference was statistically significant （P〈 0.05）. The preventive drug using time and length of stay decreased to （1.98±0.93）, （11.43±2.93）d respectively. The infection rate of pregnant women in hospital decreased from 13. 33% to 2. 67%. CONCLUSION The pharmacistr s active intervention of antimicrobial agents use in prevention of puerperal infection effectively promotes the rational use of antimicrobial agents, and obviously decreases the puerperal infection rate of pregnant women.