维吾尔族子痫前期孕妇人巨细胞病毒感染与必须微量元素的相关性研究

Correlation of necessary trace elements and human cytomegalovirus infection before eclampsia of the Uygurs in pregnant women

目的探讨维吾尔族子痫前期孕妇人巨细胞病毒(HCMV)感染与必须微量元素的相关性,以期为预防维吾尔族子痫前期孕妇HCMV感染的发生提供依据。方法对2010年1月-2012年12月124例维吾尔族子痫前期产妇作为研究对象,HCMV阳性的22例患者作为观察组,其余102例阴性患者作为对照组,比较两组患者机体必须微量元素(锌、硒、铜、铁)的差异,并对可能影响子痫前期通信作者产妇发生HCMV感染的因素进行多因素logistic回归分析。结果 124例维吾尔族子痫前期产妇中,发生HCMV感染22例,感染率为17.74%;患者血清锌含量观察组为(4.226±2.241)μmol/L、对照组为(7.856±3.314)μmol/L,观察组明显低于对照组(P<0.05);观察组钙、镁含量为(19.596±3.228)mmol/L、(0.658±0.115)mmol/L,与对照组(21.724±5.472)mmol/L、(0.636±0.124)mmol/L等其他微量元素组间比较,差异无统计学意义;多因素logistic回归分析结果显示,HCMV感染(OR=2.471,β=16.091)和血清锌含量(OR=1.278,β=4.528)是子痫前期产妇HCMV感染的独立危险因素(P<0.05)。结论维吾尔族子痫前期孕妇HCMV感染除了HCMV感染史外,血清锌含量低是导致产妇发生HCMV感染的又一危险因素,值得当地女性引起重视,适当补锌减少疾病的发生。

OBJECTIVE To investigate the correlation of necessary trace elements and preeclampsia of the Uygurs pregnant women in human cytomegalovirus（HCMV）infection, in order to provide effective basis to prevent the occurrence of HCMV infection in pregnant women preeclampsia of the Uygurs. METHODS A total of 124 cases of pregnant women in eclampsia of the Uygurs from Jan. 2010 to Dec. 2012 were selected as research subjects, among which 22 patients with HCMV-positive infection were set as the observation group, and the remaining 102 cases of patients with negative results were set as the control group. Two groups were compared on necessary trace elements （ zinc, selenium, copper, iron）, and the factors might affect the occurrence of HCMV infection in pregnant women preeclampsia of the Uygurs were under the multivariate logistic regression analysis. RESULTS Among 124 cases of pregnant women with eclampsia of the Uygurs, 22 had HCMV infection, accounting for 17.74%. The serum zinc content in the observation group were （4. 226± 2. 241）μmol/L, while in the control group it was （7. 856±3. 314） μmol/L, which was significantly higher than that of observation group （P〈0.05）; the differences were not statistically significant on Ca [（19. 596± 3. 228）mmol/L vs. （21. 724±5. 472）mmol/L], Mg[（0. 658±0. 115）mmol/L vs. （0. 636±0. 124）mmol/L] and other trace elements between the two groups （P〈0.05）. Logistic regression analysis showed that HCMV infection （OR=2. 471, β= 16. 091） and serum zinc content （OR=1. 278, β=4. 528） were the independent risk factors for puerperal preeclampsiaHCMV infection （P〈0. 05）. CONCLUSION For the preeclampsia of the Uygurs pregnant women had HCMV infection, low serum zinc content is another risk factor for leading puerperal HCMV infection in addition to the history of HCMV infection, which deserves attention to the local women, and the appropriate zinc supplementation maybe reduce the occurrence of diseases.