冰黄药凝胶治疗糖尿病足溃疡的临床研究

Clinical observation of Binghuangyao gel for the treatment of diabetic foot ulcers

目的 观察冰黄药凝胶结合西药治疗糖尿病足溃疡的临床疗效.方法 将42例糖尿病足患者随机分为治疗组30例和对照组12例.2组均予西药常规降血糖及抗感染治疗.治疗组加用冰黄药凝胶敷贴患处,半个月为一疗程.治疗前后分别观察2组血糖、血脂、血浆内皮素（ET）、血栓素（TXB2）、踝肱指数、足背动脉血流参数、溃疡肉芽组织出现时间（GT）、溃疡愈合时间（HT）.结果 治疗组在血糖、ET、TXB2的变化,足背动脉血流情况的改善及溃疡肉芽组织出现时间（GT）、溃疡愈合时间（HT）均优于对照组（P ＜0.05或P＜0.01）.2组治疗后踝肱指数均与本组治疗前比较差异显著（P＜0.01）.结论 冰黄药凝胶中西医治疗糖尿病足溃疡较单纯西药治疗疗效更显著.

Objective To study the clinical effect of combination of Chinese medicine and western medicine therapy with Binghuangyao gel on diabetic foot ulcers. Methods 42 diabetic foot patients were enrolled and randomly divided into a Binghuangyao gel sticking therapy group （T group, n = 30） and a control group （C group, n = 12 ）. Patients in both groups received the same general hypoglycemic and anti - inflammatory treatment. In addition, patients in T group were treated with Binghuangyao gel with was applieated on the affected area, half a month as a treatment cycle. Glucose, lipid, endothelin （ET） , thromboxaue （TXB2 ） , ankle -brachiaJ index, ultrasonic Doppler examination in dorsalis pedis artery, granulation tissue formation time （GT）, and ulcer healing time （HT） were observed before and after treatment. Results The improvement of glucose, ET, TXB2 , blood flow of dorsalis pedis artery, GT, and HT were observed in T group compared with with C group （P 〈 0.05 or P 〈 0.01 ）. Significant difference on ankle - brachial index was observed in both groups before and after treatment （P 〈 0.01 ）. Conclusion Combination of Chinese medicine and western medicine therapy with Binghuangyao gel sticking is better than the simple comprehensive treatment with western medicine.