进展性脑梗死患者的炎症因子变化

Changes of the levels of inflammatory factors in progressive cerebral infarction

目的对进展性脑梗死患者的血清炎症因子水平的变化情况进行观察分析。方法选择进展性脑梗死患者、非进展性脑梗死患者及健康人群个体共105例作为研究对象，按患病类型和健康情况将其分为进展性脑梗死组、非进展性脑梗死组和健康人群对照组，每组各35例，对研究对象超敏C-反应蛋白（hs—CRP）、白细胞介素-8（IL-8）、肿瘤坏死因子-α（TNF-α）和血清前白蛋白（ei）进行检测观察。结果进展性脑梗死组和非进展性脑梗死组患者的hs—CRP、IL-8、TNF-α水平均较对照组显著偏高（P〈0．05），且进展性脑梗死组较非进展性脑梗死组更高（P〈0．05）；与对照组比较，进展性脑梗死组和非进展性脑梗死组患者的血清PA水平明显偏低（P〈0．05）．且进展性脑死组较非进展性脑梗死组更低（P〈0．05）。结论血清hs，CRP、IL-8、TNF-α、PA等炎症因子水平变化对进展性脑梗死的发病有一定的提示作用。

Objective To observe and analyze the changes of the levels of inflammatory factors in patients with progressive cerebral infarction. Methods One hundred and five individuals of the pa- tients with progressive cerebral infarction, the patients with non-progressive cerebral infarction and healthy individuals were selected as the research objects. The objects were divided into the progressive cerebral infarction group, the non-progressive cerebral infarction group and the control group according to the disease type and health condition. Thirty-five individuals were included in each group. The levels of high-sensitivity C-reactive protein （ hs-CRP）, interleukin-8 （ IL-8 ）, tumor necrosis factor alpha （ TNF-α） and prealbumin （PA） of the research objects were detected and observed. Results The levels of hs- CRP, IL-8 and TNF-α of the progressive cerebral infarction group and non-progressive cerebral infarction group were significantly higher than those of the control group （P 〈 0. 05 ）, and the levels of the progressive cerebral infarction group were significantly higher than those of the non-progressive cerebral infarction group （P 〈 0.05 ） ; Compared with the control group, the level of PA of the progressive cerebral infarction group and non-progressive cerebral infarction group were significantly lower （ P 〈 0. 05 ）, and the level of the pro- gressive cerebral infarction group was lower than that of the non-progressive cerebral infarction group （P 〈 0. 05）. Conclusions The changes of the inflammatory factors levels such as hs-CRP, IL-8, TNF-α, PA have certain predicative value on the development of the progressive cerebral infarction.