急性脑梗死患者H-FABP检测结果的临床分析

Clinical analysis of serum H-FABP level in the patients of acute cerebral infarction

目的探讨急性脑梗死的危险因素与心肌型脂肪酸结合蛋白(H-FABP)血清水平的关系,评价检测H-FABP在急性脑梗死的早期诊断、评定临床治疗和预后中的价值。方法对126例急性脑梗死的患者,检测H-FABP在急性脑梗死的早期血清水平值,分析年龄、最大梗死面积、高血压、糖尿病、高脂血症、意识障碍程度、应激性血糖增高与H-FABP血清水平的关系。结果急性脑梗死临床资料与血清H-FABP水平分析提示:最大脑缺血面积和糖尿病并发症与血清H-FABP水平差异有统计学意义,年龄、高血压、高脂血症、意识障碍程度和应激性血糖增高与血清H-FABP水平差异无统计学意义。急性脑梗死发生后1 h和3 h血清H-FABP水平与梗死面积有关,随着梗死面积的增大,患者血清H-FABP水平也增高(P<0.05)。糖尿病急性脑梗死患者血清H-FABP水平均高于非糖尿病急性脑梗死患者(P<0.05)[30 min:糖尿病组(8.03±0.41)μg/L高于非糖尿病(4.65±0.32)μg/L;1 h:糖尿病组(11.48±0.52)μg/L高于非糖尿病组(6.74±0.38)μg/L;3 h:糖尿病组(18.67±0.48)μg/L高于非糖尿病组(8.89±0.53)μg/L;6 h:糖尿病组(12.59±0.55)μg/L高于非糖尿病组(8.81±0.37)μg/L]。结论急性脑梗死后H-FABP水平也增高是多因素的,有可能作为急性脑梗死诊断、评定临床治疗和预后的重要指标。

ObjectiveTo observe the relationship between the risk factors of acute cerebral infarction and serum H-FABP level and to evaluate the value of H-FABP measurement in the early diagnosis, treatment and prognosis of acute cerebral infarction.MethodsTodetect serum levels of H-FABP in the patients of acute cerebral infarction, and to analysis serum H-FABP level in the 126 cases of acute cerebral infarction by age, infarction area, hypertension, diabetes, hyperlipidemia, level of consciousness, stress hyperglycemia.ResultsClinical data analysis suggests that maximum area of cerebral ischemia and diabetic complications was statistically significant with serum H-FABP level in the patients of acute cerebral infarction H-FABP. Age, hypertension, hyperlipidemia, level of consciousness and stress hyperglycemia were not statistically significant with serum H-FABP level. Serum H-FABP level increased with infarct area at 1 hour and 3 hours after the onset of acute cerebral infarction（P〈0.05）. Diabetic patients with acute cerebral infarction were higher than non-diabetic patients with acute cerebral infarction in H-FABP level （P〈0.05）[30 min： （8.03±0.41）μg/L in diabetes higher than（4.65±0.32）μg/L in non-diabetic patients; 1 h：（11.48±0.52）μg/L in diabetes higher than （6.74±0.38）μg/L; 3 h：（18.67±0.48）μg/L in diabetes higher than （8.89±0.53）μg/L;6 h：（12.59±0.55]μg/L in diabetes higher than （8.81±0.37）μg/L]. Conclusion The increase of serum H-FABP level after acute cerebral infarction is multifactorial. The serum H-FABP level may be the clinical assessment indicators as acute cerebral infarction diagnosis, treatment and prognosis.