偏头痛患者血清中过氧化物酶体增殖物激活受体γ水平研究

Changes of serum PPARγ level in migraine patients

目的观察不同时期及不同亚型偏头痛患者血清中过氧化物酶体增殖物激活受体γ(peroxisome proliferator-activated receptorγ,PPARγ)水平变化,探讨其与偏头痛的关系及临床意义。方法收集偏头痛患者105例,随机分成偏头痛发作期组(A组,n=47)和偏头痛发作间期组(B组,n=58),再根据患者有无先兆症状进一步分成四个亚组,同时选取100例健康者作为对照组。采用酶联免疫法(ELISA)检测受试者血清PPARγ水平,采用SPSS系统软件进行统计分析。结果偏头痛患者发作期PPARγ水平明显低于发作间期及健康对照者(P<0.01);发作间期的PPARγ水平与健康对照者相比无明显统计学差异(P>0.05);有先兆与无先兆发作期PPARγ水平比较无明显差异(P>0.05);有先兆和无先兆发作间期PPARγ水平无明显统计学差异(P>0.05)。结论偏头痛发作时血清PPARγ下调,其可能是偏头痛发病的潜在机制之一。有无先兆对PPARγ水平无明显影响。

Objective To investigate the PPARγlevel in serum and its relationship with migraine and clinical implications. Methods Hundred and five patients with migraine were divided into two main groups：attack period group （n=47） and attack free period group （n=58）. According to the patients with or without aura symptoms patients were further divided into four subgroups. One hundred cases of healthy were taken as control. The serum levels of PPARγ were measured using enzyme-linked immunoassay （ELISA）. Results The PPARγlevels in patients with migraine during headache attack period were significantly lower than those during headache free period and healthy control group （P〈0.01）. The PPARγ levels in headache free period had no significant difference to healthy control group （P〉0.05）. Conclusions Migraine inflammatory cells immune activation may be associated with lower PPARγ, and participate in the onset of migraine. The PPARγlevel reduction is one of the underlying mechanisms of migraine pathogenesis.