2型糖尿病合并代谢综合征患者周围神经损害相关因素的研究

The peripheral neuropathy related factor study in type 2 diabetic patients with metabolic syndrome

目的运用神经传导检测,探讨合并代谢综合征(MS)是否加重2型糖尿病患者周围神经损害并分析相关因素。方法选取符合2型糖尿病诊断标准的患者258例,测定血压、体重、腰围、空腹血糖、胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白、体重指数、神经传导,记录病史,根据MS诊断标准分为合并MS组145例和非合并MS组113例,并与100例健康人对照。结果与非合并MS组比较,合并MS组收缩压、体重、体重指数、腰围、感觉传导速度减慢、运动传导潜伏期延长及感觉运动传导波幅下降差异有统计学意义(P均<0.05);与对照组比较,合并MS组及非合并MS组均有感觉传导速度减慢、运动传导潜伏期延长及感觉运动传导波幅下降差异有统计学意义(P均<0.05)。结论合并MS的2型糖尿病患者周围神经损害更重,可能与收缩压、体重、体重指数、腰围有关。

Objective To probe whether metabolic syndrome causes greater damage to the peripheral nerves of a patient with type 2 diabetes and analyze related factors. Methods Selecting 258 patients in accordance with the diagnostic criteria for type 2 diabetes, measuring their blood pressure, weight, waistline, fasting blood-glucose, cholesterol, triglyceride, low-density lipoprotein and high-density lipoprotein, body mass index, nerve conduction, recording medical history, dividing them into two groups in accordance with the diagnostic criteria for MS：the combine MS group with 145 cases and the non-combine MS group with 113 cases, and contrasting them with 100 healthy people. Results Compared with the non-combine MS group, the differences that the combine MS group had in systolic pressure, body weight, body mass index, waistline, sensory nerve conduction velocity, motor nerve conduction latent period delaying and sensory motor nerve conduction amplitude were statistically significant（P〈0.05）. Compared with control group, both combine MS and non-combine MS groups＇ sensory nerve conduction slowed down, motor nerve conduction latency prolonged and sensory motor nerve conduction amplitudes decreased, so the differences were also statistically significant （P〈0.05）. Conclusion Metabolic syndrome causes greater damage to the peripheral nerves of a patient with type 2 diabetes It may be associated with systolic pressure, body weight, body mass index and waistline.