原发性肝癌患者胆汁蛋白质组学的研究现状

Research status of biliary proteomics in primary liver cancer patients

肝癌患者胆汁中的蛋白质多已完成细胞内组装、酶解、剪切等翻译后修饰过程,变异较小、检测的可重复性高,且成分相对简单、肿瘤相关蛋白的局部浓度高、背景干扰小。因此,运用蛋白质组学的研究方法,以胆汁为研究对象,进行高通量、全信息的蛋白质组学研究,对肝癌的早期诊断及病理分析可能有潜在的研究前景及重要的临床价值。

Bile protein in primary liver cancer has completed assembly, digestion, and shear process of modification after translation in the cell. It shows less variability, high repeatability of detection. The content is relatively simple, local concentrations of tumor associated protein are high, and background interference is mere. Therefore, the high flux and comprehensive information research of bile, using proteornics method, may have potential research prospect and important clinical value in early diagnosis and pathological analysis of primary liver cancer.