肾小管上皮-间充质转化的研究现状

Research status of tubular epithelial-mesenchymal transition

肾小管间质纤维化(TIF)几乎是所有慢性肾脏病进展至终末期肾病(ESRD)的最终共同通路,肾小管上皮-间充质转化(EMT)是TIF的关键发病机制,成为目前肾脏领域研究的热点。本文旨在综述肾小管EMT的研究现状,总结目前肾小管EMT研究存在的问题及展望,为今后肾小管EMT的研究以及TIF的治疗提供新的思路。

Renal tubular interstitial fibrosis （TIF） is the final common pathway of a wide variety of chronic kidney diseases that eventually lead to end-stage renal disease （ESRD）. Growing evidence has implicated tubular epithelial-mesenchymal transition （EMT） as a major pathway leading to TIF in diseased kidneys. Therefore, EMT has become the focus of research in kidney diseases. The purpose of this study is to review the status of renal tubular EMT. It also summarizes the remaining problems and prospects for future research to provide new clues for the study of tubular EMT as well as the treatment of TIF.