丁苯酞对急性缺血性脑卒中患者血清C-反应蛋白的影响及临床疗效观察

The influence of dl-3n-butyphthalide on serum CRP level and the clinical curative effect in patients with acute ischemic stroke

目的探讨丁苯酞对急性缺血性脑卒中患者血清C-反应蛋白的影响及其临床疗效。方法将146例AIS患者随机分为观察组及对照组,观察组在常规治疗的基础上加用丁苯酞胶囊,而对照组加用纤溶酶,治疗2周后观察其临床疗效及血清C-反应蛋白的变化。结果观察组有效率明显高于对照组;治疗2周后,两组患者的CRP水平及NIHSS评分较治疗前均明显降低(P<0.05),观察组CRP水平及NIHSS评分降低更为明显,差异具有统计学意义(P<0.05)。结论应用丁苯酞可以显著降低AIS患者血清CRP浓度,显著改善其预后。

Objective To explore the influence of dl-3n-butyphthalide on serum C-reactive protein（CRP） level and the clinical curative effect in patients with acute ischemic stroke. Methods A total of 146 patients with AIS were randomly divided into observation group and control group, the observation group received dl-3n-butyphthalide on the basis of conventional treatment,but the control group received fibrinolytic enzyme. Observed the clinical efficacy and the ex- pression of C-reactive protein after the treatment for 2 weeks. Results The effect for the observation group was signifi- cantly higher than that of the control group （/9 〈0.05）. After the treatment for 2 weeks,the expression of C-reactive pro- tein and NIHSS scores of the two groups were significantly lower than that with no treatment（P〈0.05）, but the two indi- cators of the observation group were more significantly decreased than that of the control group （P 〈0.05）. Conclusion The dl-3n-butyphthalide could significantly decrease the level of CRP in patients with AIS, and it could significantly improve the prognosis of patients with AIS.