摘要
目的研究E-cadherin在颅咽管瘤中表达情况,探讨E-cadherin异常表达与颅咽管瘤侵袭相关性。方法对71例颅咽管瘤进行HE染色及E-cadherin免疫组织化学检测。结果 E-cadherin均低表达于侵袭性颅咽管瘤基底细胞和漩涡样细胞簇中;E-cadherin正常表达于非侵袭性细胞膜中。结论 E-cadherin的表达减少与颅咽管瘤的侵袭性相关,是侵袭性颅咽管瘤的标志性因子。
Objective To research expression of E-cadherin and to explore relationships between abnormal expression and invasion. Methods HE staining and immunohistochemical staining of E-cadherin were performed in 71 patients with craniopharyngioma. Results Immunostaining result showed low expression of E-cadherin in predominantly com- pactly cohesive epithelial cells within the whorl-like arrays and palisaded cells in invasive adamantinomatous cranio- pharyngioma, but normal expression in no invasive eraniopharyngioma. Conclusion Low expression of E-eadherin only presents in adamantinomatous eranipharyngioma, which is closely associated to invision, which is marker of invasive eraniopharyngioma
出处
《中国现代医生》
2014年第2期154-155,共2页
China Modern Doctor
基金
吉林省吉林市科技发展项目(201339089)
