甲状腺与乳腺多原发肿瘤的临床特征分析

Clinical features of multiple primary thyroid and breast cancer

目的 分析甲状腺与乳腺多原发肿瘤的临床特征.方法回顾性分析2003年2月～2013年6月我院经手术及病理证实的45例甲状腺与乳腺多原发肿瘤患者的临床资料.结果先证肿瘤部位对第二原发肿瘤良恶性有显著影响（P〈0.01）;以恶性乳腺肿瘤并发恶性甲状腺肿瘤的危险性更高（P〈0.01）.甲状腺肿瘤C组与对照组的ER强阳性率差异有显著性（P〈0.01）,C组的ER强阳性率更高;C组甲状腺与乳腺肿瘤ER免疫组化表达呈显著正相关（P〈0.01）.结论 ＞40岁的甲状腺肿瘤、＞50岁的乳腺肿瘤发生良性第二原发肿瘤的危险性较大,且发生间隔时间越长,对应部位第二原发肿瘤恶性的危险性更大.雌激素调节在甲状腺与乳腺多原发肿瘤病程中具有重要作用.

Objective To analyze the clinical features of multiple primary thyroid and breast cancer. Methods Retrospective analyzed clinical data of surgery and pathology confirmed 45 cases thyroid and breast multiple primary tumors （included benign and malignant）. Results The proband of the second primary tumor benign and malignant tumors had good effect （P 〈0.01 ）;Malignant breast tumor complicated with malignant thyroid tumors at higher risk （P〈0.01）. Thyroid tumors in group C and the control group strongly ER positive rate had significant difference（P〈0.01 ）, C group the positive rate of ER powerful higher; C group thyroid and breast cancer immunohistochemical expression of ER was a significant positive correlation （P〈0.01）. Conclusion Thyroid tumors greater than 40 years old ,over 50 years of benign mammary tumorigenesis second primary cancer risk is greater and longer interval occurs, the corresponding parts of the second primary malignant tumors greater risk. Estrogen-regulated in thyroid and breast disease with multiple primary tumors has an important role.