硝苯地平缓释片联合吲达帕胺治疗原发性高血压的临床疗效观察

Clinical efficacy of nifedipine sustained-release tablets combined indapamide in treatment of essential hypertension

目的观察硝苯地平缓释片联合吲达帕胺治疗原发性高血压的疗效。方法 56例经确诊的原发性高血压患者按照入院先后顺序分为A组(硝苯地平缓释片联合吲达帕胺治疗)28例和B组(单用硝苯地平缓释片治疗)28例,比较两组治疗后血压控制效果。结果治疗后2个月评价两组的疗效,A组总有效率达92.9%,B组总有效率75.0%,两组总有效率比较,差异存在显著性(P<0.05)。A组患者治疗后SBP、DBP的变化较治疗前及B组改善更明显(P<0.05)。结论硝苯地平缓释片联合吲达帕胺二者联用治疗原发性高血压具有协同降压作用,且安全方便,值得广泛推广和应用。

Objective To observe the effect of nifedipine sustained-release tablets joint indapamide in treatment of essential hypertension. Methods The 56 cases patients with essential hypertension diagnosed in accordance with the admission order were randomly divided into 28 cases of group A （nifedipine joint indapamide therapy） and 28 cases of group B （single nifedipine treatment） ; the effects were compared between the two groups after treatment. Results After treatment two months evaluation of the efficacy of the two groups,the total effective rate of group A was 92.9%, the total effective rate of group B was 75.0%,the differences of the total effective rate between the two groups was significant （P〈 0.05）. SBP,DBP changes after treatment of the patients in group A improved significantly than before treatment and group B （P〈0.05）. Conclusion Nifedipine sustained-release tablets joint indapamide in treatment of essential hypertension have synergistic antihypertensive effect and safety and convenience, should be popularized and applied.