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曲妥珠单抗治疗表皮生长因子受体-2高表达乳腺癌的护理 被引量:2

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摘要 表皮生长因子受体-2 (HER-2)是一种原癌基因,当癌细胞内的HER-2基因高表达时,细胞膜上会产生过多的HER-2蛋白,刺激癌细胞的增长,增加癌细胞的侵袭性.HER-2阳性乳腺癌患者的病情较为凶险,容易复发转移,生存期较短,预后差[1],而20%~30%的乳腺癌患者HER-2阳性[2].
作者 柴雷明
机构地区 宁波市第二医院
出处 《现代实用医学》 2014年第1期106-107,共2页 Modern Practical Medicine
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参考文献6

  • 1Banning M. Advanced breast cancer:aetiology,treatment and psy chosocial features[J].{H}British Journal of Nutrition,2007,(2):86-90.
  • 2Stem DF,Heffeman PA,Weinberg RA. P185,a product oflhe neuproto-oncogene is a receptorlke protein associated with ty rosine kinase activity[J].Mol Cell Bid,1986.1729-1740.
  • 3狄根红,沈镇宙,邵志敏.赫赛汀在转移性乳腺癌治疗中的应用和进展[J].实用癌症杂志,2003,18(6):664-666. 被引量:20
  • 4王莉萍,沈坤炜,沈镇宙.赫赛汀在乳腺癌新辅助治疗与辅助治疗中的新进展[J].中华肿瘤杂志,2006,28(4):241-243. 被引量:26
  • 5潘宏铭;徐农.肿瘤内科疾病临床治疗与合理用药[M]{H}北京:科学技术文献出版社,200747.
  • 6方琼;斐艳.乳腺癌常用化疗及靶向药物使用操作及护理要点[M]{H}上海:上海科学技术文献出版社,2011118-119.

二级参考文献20

  • 1[1]Stern DF, Hefferman PA, Weinberg RA. p185, a product of the neu proto-oncogene,is a receptorlike protein associated with tyrosine kinase activity[J]. Mol Bell Biol, 1986,6(5): 1729.
  • 2[2]Chong D, Cooke TG, Reeve JR, et al. Quantification of EGFR and c-erbB-2 expression in preinvasive compared to invasive breast cancer[J]. Eur J Cancer, 1999,35(Suppl 4) :203.
  • 3[3]Allred DC, Clark GM, Molina R, et al. Overexpression of HER-2/neu and its relationship with other prognostic factors change during the progression of in situ to invasive breast cancer[J]. Hum Pathol, 1992,23(9) :974.
  • 4[4]Thomas E,Buzdar A,Theriault R,et al. Role of paclitaxel in adjuvant therapy of operable breast cancer: preliminary results of prospective randomised clinical trial[J]. Proc Am Soc Clin Oncol,2000,19:74.
  • 5[5]Strickland LB, Dawson PJ. The hyperplasia-to-carcinoma sequence in the breast: immunohistochemical-histologic correlations [J]. Appl Immunohistochem Mol Morphol, 2000,8 (2): 9.
  • 6[6]Cobleigh MA,Vogel CL,Tripathy D,et al. Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metasta-tic disease [J]. J Clin Oncol, 1999,17 (9): 2639.
  • 7[7]Slamon DJ,Leyland-Jones B,Shak S,et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2 [J]. N Engl J Med, 2001, 344(11):783.
  • 8[8]Pegram M,Hsu S,Lewis G,et al. Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for the treatment of human breast cancers[J]. Oncogene, 1999,18(13):2241.
  • 9[9]Leyland-Jones B. Integration of Herceptininto breast cancer treatment algorithms[J]. Anti-Cancer Drugs,2002,13(suppl): 100.
  • 10[10]Slamon D, Leyland-Jones B, Shak S, et al. Addition of Herceptin(humanized anti-HER2 antibody) to first line chemotherapy for HER2 overexpressing metastatic breast cancer(HER2 +/MBC) markedly increases anticancer activity: a ran-domized,multinational, controlled phase Ⅲ trial [J]. Proc Am Soc Clin Oncol, 1998,17: 98a.

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