小剂量奈达铂联合放疗对食管癌患者免疫功能的影响

Effect of low-dose nedaplatin combined with radiotherapy on the immune function of patients suffered from esophageal Carcinoma

目的探讨小剂量奈达铂联合放疗对食管癌患者免疫功能的影响。方法将100例不宜手术的中晚期食管癌首程放疗患者随机分为奈达铂增敏放疗组(实验组)50例和单纯放疗组(对照组)50例,两组放射治疗方法采用常规或适形放疗,实验组给予奈达铂20 mg/周,静滴,于放疗开始后的每周一给药,连用6次至结束。应用流式细胞仪测定患者治疗前后外周血T淋巴细胞亚群及NK细胞比例。结果48例患者完成放疗增敏计划,全部患者完成放疗计划,两组患者临床资料具有可比性。白细胞下降、血红蛋白下降、胃肠道反应及放射性食管炎的发生率两组无显著差异。实验组与对照组比较,治疗前后各项免疫指标均无显著性差异。实验组有2例发生奈达铂过敏反应。结论小剂量奈达铂联合放疗在提高食管癌放疗患者的近期疗效的同时不影响患者的机体免疫功能。

Objective To evaluate the effect of Low-dose Nedaplatin combined radiotherapy on the immune function of patients with esophageal carcinoma Methods The patients （ n = 100 ） with um＇esectable esophageal carcinoma were divided into the radiosensitization group （ RS, n = 50 ） and the single-radiotherapy group （RT, n = 50 ） randomly. The patients in the RS group received radiotherapy combined with low-dose nedaplatin （20rag/W, id） ,while those in the RT group received radiotherapy alone. The proportion of peripheral blood T lymphocyte subsets and NK cells were measured by flow cytometry before and after treatment. Results 48 patients completed the radiosensitization and all patients completed radiotherapy. The clinical date of the two groups was comparable. There were no significant differences between the two groups such as the occurrence of leueopenia, anemia, esophagitis, nausea and vomiting. There were two cases suffered allergic reactions to nedaplatin in RS group. Conclusions Low-dose nedaplatin combined with radiotherapy proved to be effectively for esophageal carcinoma, and has no adverse effect on the immune function.