1412株金黄色葡萄球菌耐药状况分析

Analysis on Antibiotic Resistance of 1412 Staphylococcus Aureus

目的调查分析本院金黄色葡萄球菌检出情况及其对常用抗菌药物的耐药谱动态变化。方法应用回顾性调查方法，对本院从2003—01～2012—12间临床样本分离的金黄色葡萄球菌的药敏试验进行对比统计分析。结果总共1412株金黄色葡萄球菌占革兰阳性菌的35．9％，金黄色葡萄球菌MRSA检出率达到70％；十年里金黄色葡萄球菌对常用抗菌药物的耐药率总体呈上升趋势，尚未发现耐万古霉素菌株。结论本院金黄色葡萄球菌耐药率有显著性变化，多重耐药现象严重，临床合理用药是防止金黄色葡萄球菌的感染率攀升的重要措施。

Objective To investigate the changes and characteristics of antibiotic resistance spectrum of Staphylococcus aureus in the hospital. Methods Staphylococcus aureus that isolated from clinical samples and their resistances to antibiotic in the hospital from Jan 2003 to Dec 2012 were analyzed and studied retrospectively. Results A total of 1 412 strains of Staphylococcus aureus were isolated from G ＋ bacteria （35.9%）, among which MRSA accounted for about 70%. There was an elevated tendency of the drug resistance rates to common antibacterials in Staphylococcus aureus during the past ten years. Conclusion Staphylococcus aureus had an elevated tendency on drug resistance rates, and the phenomenon of multi-drug resistance was serious. Rational application of clinical medicine is very important to prevent infection.