几种药物对吗啡相关的条件位置偏好影响的研究进展

Research Progress of Drugs Related to Morphine Conditioned Place Preference

条件化位置偏好(conditioned place preference,CPP),常用于研究药物成瘾的相关记忆。这里主要综述了一些药物对CPP的影响。神经肽S,神经肽FF,肌肽,孤啡肽,α-2受体激动剂,L-左旋千金藤啶碱,东莨菪碱,丙戊酸钠,巴氯芬对吗啡CPP有抑制效应;聚肌胞苷酸,氟伏沙明和金刚烷胺能增强吗啡CPP;阿坎酸能抑制乙醇和某些类别的滥用药物的条件化奖赏效应,但不影响吗啡引起的条件化奖赏效应;褪黑激素逆转吗啡诱导的奖赏效应;人重组干扰素-α导致吗啡CPP的恢复。

Conditioned place preference （cpp）was used in studying drug addiction related to memory. Here we mainly reviewed the effect of some drugs on cpp. Neuropeptide S and neuropeptide FF, camosine, opioid peptide noeiceptin, α-2 agonists, l-stepholidine, scopolamine, valproate sodium, baelofen impaired morphine cpp; polyinosinic-polycytidylic acid, fluvoxamine and amantadine anti enha- nced morphine cpp; anti-relapse compound acamprosate suppressed ethanol and certain categories of drug abuse, but had no effect on morphine cpp; elatonin melatonic reversed of morphine-induced the rewarding effect; recombinant human interferon-α can retrieved morphine epp.