PDGF-D和VEGF在宫颈鳞癌中的表达及其意义

PDGF-D and VEGF in Cervical Squamous Carcinoma of the Expression and its Significance

目的:检测宫颈鳞癌组织中血小板源性生长因子D(PDGF-D)和血管内皮生长因子(VEGF)的表达,探讨二者在宫颈癌变过程中的作用及意义,为探讨宫颈鳞癌的发病机制和宫颈鳞癌的早期治疗提供理论依据。方法:采用免疫组织化学(SP法)检测40例宫颈鳞癌和10例正常宫颈组织中PDGF-D和VEGF蛋白的表达,分析两者之间的相关性及其与临床病理特征之间的关系。结果:宫颈鳞癌组织中PDGF-D和VEGF蛋白的表达显著高于正常宫颈组织(P<0.05);PDGF-D和VEGF的表达与宫颈鳞癌的分化程度及淋巴结转移有关(P<0.05);与年龄及临床分期无关(P>0.05)。Spearman相关分析发现PDGF-D与VEGF表达程度呈正相关(r=0.346,P<0.05)。结论:1.PDGF-D和VEGF在宫颈鳞癌组织中特异性高表达,可能在宫颈鳞癌的发生、发展与转移中起着重要作用。2.PDGF-D和VEGF表达与宫颈鳞癌的分化程度及淋巴结转移有关,与年龄及临床分期无关,提示它们可能在宫颈鳞癌的浸润和转移及预后方面有重要的监测意义。3.PDGF-D和VEGF在宫颈鳞癌组织中的表达呈正相关,提示两者起着相互促进的作用,对PDGF-D和VEGF的联合检查,为临床实际应用提供了参考。

Objective： Detection of cervical squamous cell carcinoma tissue in platelet-derived growth factor D （PDGF-D） and vascular endothelial growth factor （VEGF） expression, probe into the two in cervical carcinogenesis in the role and significance, in order to investigate the pathogenesis of cervical squamous cell carcinoma and squamous cell carcinoma of the cervix and provide theoretical basis for early treatment. Methods： Detection of cervical squamous cell carcinoma tissue in platelet-derived growth factor D （PDGF-D） and vascular endothelial growth factor （VEGF） expressionpro, be into the two in cervical carcinogenesis in the role and significance, in order to investigate the pathogenesis of cervical squamous cell carcinoma and squamous cell carcinoma of the cervix and provide theoretical basis for early treatment. Results： Cervical squamous cell carcinoma and the expression of VEGF protein in PDGF-D was significantly higher than that in normal cervical tissue （P〈0.05）; PDGF-D and VEGF expression in cervical squamous cell carcinoma and differentiation and lymph node metastasis （P〈0.05）; with age and independent of clinical stage （P 〉 0.05）. Spearman correlation analysis found that PDGF-D and VEGF expression was a positive correlation between degree （r=0.346, P〈0.05）. Conclusion： 1. PDGF-D and VEGF in cervical squamous carcinoma tissue specificity high expression, may be in cervical squamous carcinoma of the occurrence, development and transfer plays an important role. 2. PDGF-D and VEGF expression and cervical squamous carcinoma of the differentiation degree and lymph node metastasis related, and age and clinical staging has nothing to do, prompt they may in cervical squamous carcinoma invasion and metastasis and prognosis of have an important monitoring significance. 3. PDGF-D and VEGF in cervical squamous carcinoma tissue of the positive correlation between expression, indicating both plays the role of the mutual promotion of PDGF - D and VEGF joint inspection, for clinical application provides reference.