肿瘤放化综合治疗中的靶向研究

Targets for Combined Chemoradiation Cherapy in Cancer Treatment

放化疗综合应用是癌症治疗中的常用方法。研究表明,放化疗综合应用可以有效地控制杀伤肿瘤,但过程中对正常细胞的毒副作用严重制约着放化疗的剂量和疗效。如何在有效杀伤肿瘤细胞的同时减轻放化疗综合应用中对正常细胞的毒副作用已经成为探索更好的治疗策略的关键。随着研究的不断深入,各种相关的新药和新治疗思路层出不穷,比如针对肿瘤发生及代谢过程的靶向类新药、用于辐射增敏的新的基因靶点等都已进入研究者的视线。另外,近年来关于肿瘤细胞中药物转运蛋白的研究也为综合治疗靶点寻找提供了一定依据。本文根据当前研究现状,着重总结近年来放化疗综合治疗靶向研究在上述几方面的一些新进展。

The combination of chemotherapy and radiotherapy is a strategy commonly used for treatment of cancer patients. It can control and eliminate tumor efficiently. However, cytotoxicity to normal cells limits the dose and effectiveness of the combination therapy. Therefore, it becomes an essential issue to develop methods that can reduce cytotoxicity to normal cells while retain the killing effect on malignant cells. In recent years, quite a few novel therapeutics and strategies have been developed and proposed, such as some targeted drugs against the growth and metabolism of cancer cells, gene targets for radiosensitivity. In addition, the research of drug trans- porters in recent years provides some basis for the searching of therapeutic targets. This paper summarized some new methods and targets that may find some use in the future application of combination therapy.