间充质干细胞对急性肺损伤作用机制的研究进展

The progress of mechanisms of mesenchymal stem cells in acute lung injury

间充质干细胞（mesenchymal stem cells,MSCs）作为一类来源广泛的低免疫原性多能干细胞已被用于多种危重症疾病及免疫性疾病的细胞治疗研究.大量临床研究显示,MSCs尽管在受损组织中的定植率低,但可以通过旁分泌因子来调节机体免疫、抑制炎症反应、修复受损上皮.儿童急性肺损伤（acute lung injury,ALI）是严重器官功能障碍时发生最早的并发症,目前尚无有效的药物治疗,病死率高.研究显示MSCs可以有效减轻肺水肿、改善肺功能,降低病死率,对于其作用机制的了解有利于推动MSCs从实验阶段转化为临床应用.本文将重点对MSCs修复ALI的相关机制进行综述.

As a kind of source wide,low inherent immnunogenicity multipotent stromal cells,mesenchymal stem cells （MSCs） have been used to cell-based therapeutic researches of immunodeficient deseases or other severe clinical disorders.Despite low levels of engraftment in the injured lung,numerous preclinical trials indicate that mesenchymal stem cells can promote damaged tissue repair constructed by secreting paracrine factors to regulate the host immunity,inhibit inflammation and restore epithelial integrity.Acute lung injury（ALI） is a serious organ dysfunction occurred earliest and the most commonly affected organ.Currently there is no effective medicine therapy and the mortality remains high.Researches demonstrate MSCs can reduce alveolar edema,improve lung function and reduce motality.So understanding of the mechanism will be conductive to the MSCs from experimental stage into clinical application.This issue will put a brief overview pointed on the mechanism of mesenchymal stem cells in repairing the injured lung.