银屑病和SLE患者T细胞亚群与淋巴细胞CD2分子的相关性研究

Correlation of T Lymphocyte Subpopulation and Lymphocyte CD2 in Patients with Psoriasis and SLE

目的:研究银屑病和系统性红斑狼疮(systemic lulups erythematosus,SLE)患者T淋巴细胞CD2、CD4+、CD8+以及CD4+/CD8+的变化及其相关性。方法:应用流式细胞仪检测我院收治的62例银屑病和31例SLE患者T淋巴细胞CD2、CD4+、CD8+及CD4+/CD8+分子的表达水平并统计学分析其相关性。结果:银屑病患者T淋巴细胞CD4+/CD8+的比值与正常对照组比较显著增高,而SLE患者与正常对照组比较显著降低。银屑病患者CD4+百分率与正常对照组比较显著增高,SLE患者CD8+与正常对照组比较显著增高。银屑病患者CD2与CD4+之间呈正相关(γ=0.309,P<0.05),CD4+与CD4+/CD8+之间呈显著正相关(γ=0.536,P<0.05),SLE患者CD2仅与CD4+之间呈正相关(γ=0.378,P<0.05)。结论:T淋巴细胞免疫功能紊乱可能在银屑病的发病机制中发挥了重要作用,CD2可能使银屑病的T淋巴细胞紊乱致炎症加重。SLE患者T细胞亚群CD4+/CD8+比值下降,CD2与CD4呈正相关亦可能使SLE的T淋巴细胞加速信号传导紊乱,CD8+百分率增高可能在SLE的发病机制中起重要作用。

Objective： To analyze the role of CD2, CD4＋, CD8＋and CD4＋/CD8＋of T lymphocyte in patients with psoriasis and SLE, and the correlation between them. Methods： The expression of CD2, CD4＋,CD8＋and CD4＋/CD8＋of T lymphocyte in psoriasis patients and SLE patients was measured by FCM. Results： The ratio of CD4＋/CD8＋ in patients with psoriasis was significantly higher than in normal controls（P0.001）, while that in patients with SLE was significantly lower than in normal controls（P0.001）. The percentage of CD4＋in patients with psoriasis was significantly higher than in normal controls（P0.001）; the percentage of CD8＋in the patients with SLE was significantly higher than in normal controls（P 0.001）. CD2 and CD4＋, CD4＋and CD4＋/CD8＋in psoriasis patients showed positive correlation. Conclusion： The immune function of lymphocyte was found to be turbulent in psoriasis patients.CD2 might aggravate psoriatic T lymphocytes disorders, then cause a promoting inflammation. The ratio of T subpopulation was upregulated and the relative percentage of CD4＋increased, which may be important in the pathogenesis of psoriasis. The positive correlation between CD2 and CD4 may also ma ke SLE T lymphocytes disturbance, and accelerate signal conduction. The downregulation of T subpopulation ratio and higher expression of CD8＋may be involved in the pathogenesis of SLE.