芳香开窍药嗅吸剂对急性颅脑创伤患者脑组织血供情况的影响及预后

Aromatic Resuscitation Drug Sniffing on the Blood Supply of Brain Tissue in Patients with Acute Craniocerebral Traumatic Effects and Prognosis

[目的]观察由芳香开窍药组成的嗅吸剂应用在急性颅脑创伤(traumatic brain injury,TBI)治疗中的脑组织血供情况变化及预后。[方法]选取我院TBI患者40例,按入院先后随机分为治疗组和对照组各20例,全部患者入院后均给予常规治疗,治疗组入院第2d起另给予芳香开窍嗅吸剂雾化嗅吸。两组分别于入院后第2d、第4d、第6d、第8d、第11d行颅多普勒(transcranial doppler sonography,TCD)检查脑血流变化以及神经系统检查和格拉斯哥昏迷计分法(GCS)评分。[结果]给予芳香开窍嗅吸剂治疗后,治疗组GCS评分在第6、8、11d明显高于对照组,差异有统计学意义(P<0.05和P<0.01),治疗组Vs、Vm、PI值与对照组相比明显改善,具有统计学差异(P<0.01和P<0.001)。[结论]芳香开窍药组成的嗅吸剂可以改善TBI患者的脑组织血供情况及预后,其机制可能是与芳香开窍药对脑缺血、缺氧有保护作用。

[Objective] Observation aromatic resuscitation drug composed of olfactory sucking agent application in the treatment of acute traumatic cerebral tis-sue blood supply changes and prognosis. [Methods] Craniocerebral trauma patients 40 cases admitted are randomly divided into treatment group and against group with 20 cases, al patients are given general treatment, treatment group from 2nd day given aromatic resuscitation drug olfactory sucking agent powder by atomization, two groups respectively at 2nd day, 4th day, 6th day, 8th day, and 11th day, by TCD check of brain blood flow changes and nervous system and GCS scoring. [Results] Two sets of cerebral blood flow in patients with Vs, Vm, 2 d PI values are not significantly different, aromatic resuscitation after sniffing in the treatment, the treatment group Vs, Vm, PI value compared with the control group improves significantly. [Conclusion] Aromatic resuscitation drug composed of olfactory sucking agent can improve head trauma patients of brain organization blood for situation and the prognosis, its mechanism may be aromatic resuscitation drug effect on brain deficiency blood, and hypoxia has protection role;put drug of micro-powder with nasal olfactory sucking through nasal mucosa-cerebrospinal fluid way into brain, breakthrough or bypass blood brain barrier, improving head trauma patients of brain organization blood.