超嗜热古菌基因组的热稳定性

The genomic thermostability of hyperthermophilic archaea

超嗜热古菌能够生活在80℃以上的高温环境中,它们的耐热性已经成为当前研究的热点之一。以往对超嗜热菌的认识多集中于蛋白质的耐热性,而很少有关于基因组热稳定性的综述文章。综述了当前对超嗜热古菌的基因组稳定性以及DNA损伤识别机制的研究进展,以期更好地了解超嗜热古菌的耐热机制。

Hyperthermophilic archaea is adapted to live at temperatures higher than 80℃. Their thermotolerance has become a research hotspot. Previous publications on the archaeal heat-resistant mechanism primarily focused on protein, and rarely on the genomic thermostability. Here, we reviewed the research progress on the genomic stability and DNA damage response of hyperthermophilic Archaea, and hoped to be helpful to better understand the archaeal thermostability.